Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm

Wei Feng Li; Yueh Wei Liu; Chih Chi Wang; Chee Chien Yong; Chih Che Lin; Yi Hao Yen

doi:10.1371/journal.pone.0281154

Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm

Wei Feng Li, Yueh Wei Liu, Chih Chi Wang^*, Chee Chien Yong, Chih Che Lin, Yi Hao Yen^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

Abstract

Background/objective To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liv≤er resection (LR). Methods This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. Results Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5–70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. Conclusion The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort.

Original language	English
Article number	e0281154
Pages (from-to)	e0281154
Journal	PLoS ONE
Volume	18
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0281154
State	Published - 02 2023
Externally published	Yes

Bibliographical note

Copyright: © 2023 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

Humans
Carcinoma, Hepatocellular/pathology
Liver Neoplasms/pathology
Retrospective Studies
Prognosis
Neoplasm Invasiveness/pathology
Hepatectomy
Neoplastic Processes
Neoplasm Recurrence, Local/pathology

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title = "Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm",

abstract = "Background/objective To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liv≤er resection (LR). Methods This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. Results Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5–70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. Conclusion The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort.",

keywords = "Humans, Carcinoma, Hepatocellular/pathology, Liver Neoplasms/pathology, Retrospective Studies, Prognosis, Neoplasm Invasiveness/pathology, Hepatectomy, Neoplastic Processes, Neoplasm Recurrence, Local/pathology",

author = "Li, {Wei Feng} and Liu, {Yueh Wei} and Wang, {Chih Chi} and Yong, {Chee Chien} and Lin, {Chih Che} and Yen, {Yi Hao}",

note = "Copyright: {\textcopyright} 2023 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

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T1 - Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm

AU - Li, Wei Feng

AU - Liu, Yueh Wei

AU - Wang, Chih Chi

AU - Yong, Chee Chien

AU - Lin, Chih Che

AU - Yen, Yi Hao

N1 - Copyright: © 2023 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2023/2

Y1 - 2023/2

N2 - Background/objective To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liv≤er resection (LR). Methods This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. Results Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5–70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. Conclusion The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort.

AB - Background/objective To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liv≤er resection (LR). Methods This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. Results Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5–70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. Conclusion The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort.

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KW - Carcinoma, Hepatocellular/pathology

KW - Liver Neoplasms/pathology

KW - Retrospective Studies

KW - Prognosis

KW - Neoplasm Invasiveness/pathology

KW - Hepatectomy

KW - Neoplastic Processes

KW - Neoplasm Recurrence, Local/pathology

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ER -

Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm

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Keywords

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