Mineralo-organic nanoparticles in health and disease: an overview of recent findings

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Abstract

We observed earlier that mineralo-organic nanoparticles form in human body fluids when the concentrations of calcium, carbonate and phosphate exceed saturation. The particles have been shown to represent mineral precursors in developing bones and teeth as well as in ectopic calcification and kidney stones. Recent studies suggest that the mineral particles may also be involved in other physiological processes, including immune tolerance against the gut microbiota and food antigens. We review here the involvement of mineralo-organic nanoparticles in physiological and pathological processes and discuss recent findings that reveal novel and unexpected roles for these particles in the human body.

Original languageEnglish
Pages (from-to)1787-1793
Number of pages7
JournalNanomedicine
Volume13
Issue number14
DOIs
StatePublished - 01 07 2018

Keywords

  • bions
  • calciprotein particles
  • calcium granules
  • carbonate apatite
  • ectopic calcification
  • fetuin-mineral complexes

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