miR-196, an emerging cancer biomarker for digestive tract cancers

Ya Ching Lu, T Chang Joseph T Chang, Err Cheng Chan, Yin Kai Chao, Ta Sen Yeh, Jinn Shiun Chen, Ann Joy Cheng*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

45 Scopus citations

Abstract

Over the past decade, the emergence of microRNA (miRNA) research has firmly established this molecular family as a key component in cells. MiRNAs, which function as negative gene regulators, participate in multiple biological processes and maintain homeostasis in cells. The dysregulation of miRNA may contribute to numerous human disorders, including cancer. Recently, miR-196 was found to be aberrantly expressed in a wide range of malignant diseases, which suggests that it plays important roles in carcinogenesis. Here, we summarize the current knowledge concerning miR-196 family in cancers. This review includes miR-196 gene structure and aberrant expression in various cancers, and current understanding of numerous functions and regulatory targets of miR-196 in specific cancers. Since miR-196 are consistently found over-expressed in digestive tract cancer tissues, we also reviewed the clinical significance and potential applications of miR-196 in these cancers. We highlight that miR-196 may serve as an emerging cancer biomarker for digestive tract cancers.

Original languageEnglish
Pages (from-to)650-655
Number of pages6
JournalJournal of Cancer
Volume7
Issue number6
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© Ivyspring International Publisher.

Keywords

  • Cancer
  • Clinical application
  • Regulatory mechanism
  • miR-196

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