Mirtazapine reduces adipocyte hypertrophy and increases glucose transporter expression in obese mice

Ching Feng Wu, Po Hsun Hou, Frank Chiahung Mao, Yao Chi Su, Ching Yang Wu, Wei Cheng Yang, Chen Si Lin, Hsiao Pei Tsai, Huei Jyuan Liao, Geng Ruei Chang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

11 Scopus citations


Metabolic syndrome is known to engender type 2 diabetes as well as some cardiac, cerebrovascular, and kidney diseases. Mirtazapine—an atypical second-generation antipsychotic drug with less severe side effects than atypical first-generation antipsychotics—may have positive effects on blood glucose levels and obesity. In our executed study, we treated male high-fat diet (HFD)-fed C57BL/6J mice with mirtazapine (10 mg/kg/day mirtazapine) for 4 weeks to understand its antiobesity effects. We noted these mice to exhibit lower insulin levels, daily food efficiency, body weight, serum triglyceride levels, aspartate aminotransferase levels, liver and epididymal fat pad weight, and fatty acid regulation marker expression when compared with their counterparts (i.e., HFD-fed control mice). Furthermore, we determined a considerable drop in fatty liver scores and mean fat cell size in the epididymal white adipose tissue in the treated mice, corresponding to AMP-activated protein kinase expression activation. Notably, the treated mice showed lower glucose tolerance and blood glucose levels, but higher glucose transporter 4 expression. Overall, the aforementioned findings signify that mirtazapine could reduce lipid accumulation and thus prevent HFD-induced increase in body weight. In conclusion, mirtazapine may be useful in body weight control and antihyperglycemia therapy.

Original languageEnglish
Article number1423
Pages (from-to)1-17
Number of pages17
Issue number8
StatePublished - 08 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.


  • Adipocyte
  • Blood glucose
  • Insulin
  • Mirtazapine
  • Obesity


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