Mitochondrial-associated protein biomarkers in patients with attention-deficit/hyperactivity disorder

Chia Jung Lee, Chih Ching Wu, Wen Jiun Chou, Min Jing Lee, Miao Chun Chou, Sheng Yu Lee, Liang Jen Wang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

12 Scopus citations


This study aimed to determine the role of mitochondria-associated proteins (HtrA2, α-synuclein, and Park7) in attention deficit/hyperactivity disorder (ADHD). A total of 125 patients with ADHD (77.6% were males) and 66 healthy controls (66.7% were males) were recruited. We found that girls with ADHD demonstrated higher plasma HtrA2 level than control girls, and their HtrA2 levels were positively correlated with verbal comprehensive ability, and negatively correlated to behavior symptoms. Among boys, we observed no correlations between these mitochondrial proteins, neuropsychological findings, and clinical symptoms. Our findings suggest that an underlying gender-specific mitochondria pathway may influence with the pathophysiology of ADHD.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
StatePublished - 11 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier B.V. and Mitochondria Research Society


  • ADHD
  • Biomarkers
  • Dopamine
  • Mitochondrion
  • Protein


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