Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers

Po Liang Lai; Cheng Chun Hsu; Tsang Hao Liu; Ding Wei Hong; Lih Huei Chen; Wen Jer Chen; I. Ming Chu

doi:10.1016/j.reactfunctpolym.2012.07.014

Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers

Po Liang Lai
, Cheng Chun Hsu
, Tsang Hao Liu
, Ding Wei Hong
, Lih Huei Chen
, Wen Jer Chen
, I. Ming Chu^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

mPEG-PLLA (poly l-lactic acid) is synthesized by ring-opening polymerization of lactide and conjugation with mPEG. Sebacic acid is modified with acetic anhydride and condensed with mPEG to form mPEG-PSA (poly sebacic anhydride). The micelles formed by mPEG-PLLA are characterized by slow degradation and low drug encapsulation efficiency; on the contrary, mPEG-PSA micelles are characterized by rapid degradation but high encapsulation efficiency. They can merge into spherical micelles (Φ = 140 nm) by self-assembly in water. The mixed micelles can successfully encapsulate a typical hydrophobic drug (curcumin), and significantly improve its solubility. Experimental results show that the mixed micelles have the features of high encapsulation efficiency and slow degradation.

Original language	English
Pages (from-to)	846-855
Number of pages	10
Journal	Reactive and Functional Polymers
Volume	72
Issue number	11
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2012.07.014
State	Published - 11 2012

Keywords

Diblock copolymers
Drug delivery system
Mixed micelles
Polyanhydride
Self-assembly

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10.1016/j.reactfunctpolym.2012.07.014

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title = "Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers",

abstract = "mPEG-PLLA (poly l-lactic acid) is synthesized by ring-opening polymerization of lactide and conjugation with mPEG. Sebacic acid is modified with acetic anhydride and condensed with mPEG to form mPEG-PSA (poly sebacic anhydride). The micelles formed by mPEG-PLLA are characterized by slow degradation and low drug encapsulation efficiency; on the contrary, mPEG-PSA micelles are characterized by rapid degradation but high encapsulation efficiency. They can merge into spherical micelles (Φ = 140 nm) by self-assembly in water. The mixed micelles can successfully encapsulate a typical hydrophobic drug (curcumin), and significantly improve its solubility. Experimental results show that the mixed micelles have the features of high encapsulation efficiency and slow degradation.",

keywords = "Diblock copolymers, Drug delivery system, Mixed micelles, Polyanhydride, Self-assembly",

author = "Lai, \{Po Liang\} and Hsu, \{Cheng Chun\} and Liu, \{Tsang Hao\} and Hong, \{Ding Wei\} and Chen, \{Lih Huei\} and Chen, \{Wen Jer\} and Chu, \{I. Ming\}",

year = "2012",

month = nov,

doi = "10.1016/j.reactfunctpolym.2012.07.014",

language = "英语",

volume = "72",

pages = "846--855",

journal = "Reactive and Functional Polymers",

issn = "1381-5148",

publisher = "Elsevier B.V.",

number = "11",

}

TY - JOUR

T1 - Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers

AU - Lai, Po Liang

AU - Hsu, Cheng Chun

AU - Liu, Tsang Hao

AU - Hong, Ding Wei

AU - Chen, Lih Huei

AU - Chen, Wen Jer

AU - Chu, I. Ming

PY - 2012/11

Y1 - 2012/11

N2 - mPEG-PLLA (poly l-lactic acid) is synthesized by ring-opening polymerization of lactide and conjugation with mPEG. Sebacic acid is modified with acetic anhydride and condensed with mPEG to form mPEG-PSA (poly sebacic anhydride). The micelles formed by mPEG-PLLA are characterized by slow degradation and low drug encapsulation efficiency; on the contrary, mPEG-PSA micelles are characterized by rapid degradation but high encapsulation efficiency. They can merge into spherical micelles (Φ = 140 nm) by self-assembly in water. The mixed micelles can successfully encapsulate a typical hydrophobic drug (curcumin), and significantly improve its solubility. Experimental results show that the mixed micelles have the features of high encapsulation efficiency and slow degradation.

AB - mPEG-PLLA (poly l-lactic acid) is synthesized by ring-opening polymerization of lactide and conjugation with mPEG. Sebacic acid is modified with acetic anhydride and condensed with mPEG to form mPEG-PSA (poly sebacic anhydride). The micelles formed by mPEG-PLLA are characterized by slow degradation and low drug encapsulation efficiency; on the contrary, mPEG-PSA micelles are characterized by rapid degradation but high encapsulation efficiency. They can merge into spherical micelles (Φ = 140 nm) by self-assembly in water. The mixed micelles can successfully encapsulate a typical hydrophobic drug (curcumin), and significantly improve its solubility. Experimental results show that the mixed micelles have the features of high encapsulation efficiency and slow degradation.

KW - Diblock copolymers

KW - Drug delivery system

KW - Mixed micelles

KW - Polyanhydride

KW - Self-assembly

UR - https://www.scopus.com/pages/publications/84865535654

U2 - 10.1016/j.reactfunctpolym.2012.07.014

DO - 10.1016/j.reactfunctpolym.2012.07.014

M3 - 文章

AN - SCOPUS:84865535654

SN - 1381-5148

VL - 72

SP - 846

EP - 855

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

IS - 11

ER -

Mixed micelles from methoxy poly(ethylene glycol)-polylactide and methoxy poly(ethylene glycol)-poly(sebacic anhydride) copolymers as drug carriers

Abstract

Keywords

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