Models of cortico-basal ganglia circuits and synaptic plasticity for transcranial magnetic stimulation

Yu Yang Yen, Lee Ray Chen, Ying Zu Huang, Chung Chuan Lo*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Transcranial magnetic simulations (TMS) is an effective tool for studying pathophysiology of dystonia as well as various other movement or cognitive functions of the brain. To study how TMS induces complex neuronal responses and plasticity, we built computational models for primary motor cortex, basal ganglia and synaptic plasticity. Our models have successfully reproduced neuronal responses to TMS, corresponding neural plasticity induced by a number of repetitive TMS protocols and different signal pathways in basal ganglia. With integration of the three models into a unified large-scale model (work in progress), we will be able to provide insights into neuronal mechanisms underlying the effectiveness of TMS and pathophysiology of dystonia.

Original languageEnglish
Title of host publication2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings
Pages96-100
Number of pages5
DOIs
StatePublished - 2012
Externally publishedYes
Event6th International Conference on Complex Medical Engineering, CME 2012 - Kobe, Japan
Duration: 01 07 201204 07 2012

Publication series

Name2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings

Conference

Conference6th International Conference on Complex Medical Engineering, CME 2012
Country/TerritoryJapan
CityKobe
Period01/07/1204/07/12

Keywords

  • TBS
  • TMS
  • basal ganglia
  • dystonia
  • motor cortex
  • rTMS
  • synaptic plasticity

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