Modification of clearview tuberculosis (TB) enzyme-linked immunosorbent assay for tb patients not infected with HIV

Laura Savolainen; Anu Kantele; Bettina Sandboge; Marita Sirén; Heikki Valleala; Riitta Tuompo; Liana Pusa; Riitta Erkinjuntti-Pekkanen; Aija Knuuttila; Cheng Lung Ku; Chih Yu Chi; Tuula Vasankari; Tamara Tuuminen

doi:10.1128/CVI.00375-13

Modification of clearview tuberculosis (TB) enzyme-linked immunosorbent assay for tb patients not infected with HIV

Laura Savolainen^*, Anu Kantele, Bettina Sandboge, Marita Sirén, Heikki Valleala, Riitta Tuompo, Liana Pusa, Riitta Erkinjuntti-Pekkanen, Aija Knuuttila, Cheng Lung Ku, Chih Yu Chi, Tuula Vasankari, Tamara Tuuminen

^*Corresponding author for this work

Graduate Institute of Clinical Medical Sciences

Research output: Contribution to journal › Journal Article › peer-review

16 Scopus citations

Abstract

Diagnosis of active tuberculosis by detection of urinary lipoarabinomannan (uLAM) from Mycobacterium tuberculosis is an attractive approach. Concentrating urine 100-foldallowed quantitation of uLAM at levels equal to picograms/ml of nonconcentrated urine. The approach of concentrating urine 100-fold improved the clinical sensitivity of the Clearview TB enzyme-linked immunosorbent assay (ELISA) from 7% to 57% yet impaired its specificity from 97% to 89%. (This study has been registered at University Hospital of Turku under registration no. 47/180/2009, Helsinki University Central Hospital under 149/2010, University Hospital of Kuopio under 105/2010, and China Medical University Hospital, Taichung, under DMR-99-IRB-075-2.)

Original language	English
Pages (from-to)	1479-1482
Number of pages	4
Journal	Clinical and Vaccine Immunology
Volume	20
Issue number	9
DOIs	https://doi.org/10.1128/CVI.00375-13
State	Published - 09 2013

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Savolainen, L., Kantele, A., Sandboge, B., Sirén, M., Valleala, H., Tuompo, R., Pusa, L., Erkinjuntti-Pekkanen, R., Knuuttila, A., Ku, C. L., Chi, C. Y., Vasankari, T., & Tuuminen, T. (2013). Modification of clearview tuberculosis (TB) enzyme-linked immunosorbent assay for tb patients not infected with HIV. Clinical and Vaccine Immunology, 20(9), 1479-1482. https://doi.org/10.1128/CVI.00375-13

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abstract = "Diagnosis of active tuberculosis by detection of urinary lipoarabinomannan (uLAM) from Mycobacterium tuberculosis is an attractive approach. Concentrating urine 100-foldallowed quantitation of uLAM at levels equal to picograms/ml of nonconcentrated urine. The approach of concentrating urine 100-fold improved the clinical sensitivity of the Clearview TB enzyme-linked immunosorbent assay (ELISA) from 7% to 57% yet impaired its specificity from 97% to 89%. (This study has been registered at University Hospital of Turku under registration no. 47/180/2009, Helsinki University Central Hospital under 149/2010, University Hospital of Kuopio under 105/2010, and China Medical University Hospital, Taichung, under DMR-99-IRB-075-2.)",

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Savolainen, L, Kantele, A, Sandboge, B, Sirén, M, Valleala, H, Tuompo, R, Pusa, L, Erkinjuntti-Pekkanen, R, Knuuttila, A, Ku, CL, Chi, CY, Vasankari, T & Tuuminen, T 2013, 'Modification of clearview tuberculosis (TB) enzyme-linked immunosorbent assay for tb patients not infected with HIV', Clinical and Vaccine Immunology, vol. 20, no. 9, pp. 1479-1482. https://doi.org/10.1128/CVI.00375-13

TY - JOUR

T1 - Modification of clearview tuberculosis (TB) enzyme-linked immunosorbent assay for tb patients not infected with HIV

AU - Savolainen, Laura

AU - Kantele, Anu

AU - Sandboge, Bettina

AU - Sirén, Marita

AU - Valleala, Heikki

AU - Tuompo, Riitta

AU - Pusa, Liana

AU - Erkinjuntti-Pekkanen, Riitta

AU - Knuuttila, Aija

AU - Ku, Cheng Lung

AU - Chi, Chih Yu

AU - Vasankari, Tuula

AU - Tuuminen, Tamara

PY - 2013/9

Y1 - 2013/9

N2 - Diagnosis of active tuberculosis by detection of urinary lipoarabinomannan (uLAM) from Mycobacterium tuberculosis is an attractive approach. Concentrating urine 100-foldallowed quantitation of uLAM at levels equal to picograms/ml of nonconcentrated urine. The approach of concentrating urine 100-fold improved the clinical sensitivity of the Clearview TB enzyme-linked immunosorbent assay (ELISA) from 7% to 57% yet impaired its specificity from 97% to 89%. (This study has been registered at University Hospital of Turku under registration no. 47/180/2009, Helsinki University Central Hospital under 149/2010, University Hospital of Kuopio under 105/2010, and China Medical University Hospital, Taichung, under DMR-99-IRB-075-2.)

AB - Diagnosis of active tuberculosis by detection of urinary lipoarabinomannan (uLAM) from Mycobacterium tuberculosis is an attractive approach. Concentrating urine 100-foldallowed quantitation of uLAM at levels equal to picograms/ml of nonconcentrated urine. The approach of concentrating urine 100-fold improved the clinical sensitivity of the Clearview TB enzyme-linked immunosorbent assay (ELISA) from 7% to 57% yet impaired its specificity from 97% to 89%. (This study has been registered at University Hospital of Turku under registration no. 47/180/2009, Helsinki University Central Hospital under 149/2010, University Hospital of Kuopio under 105/2010, and China Medical University Hospital, Taichung, under DMR-99-IRB-075-2.)

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U2 - 10.1128/CVI.00375-13

DO - 10.1128/CVI.00375-13

M3 - 文章

C2 - 23825194

AN - SCOPUS:84884690961

SN - 1556-6811

VL - 20

SP - 1479

EP - 1482

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 9

ER -

Modification of clearview tuberculosis (TB) enzyme-linked immunosorbent assay for tb patients not infected with HIV

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