Modifications op the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide

Guigen Li; W. Haq; Li Xiang; Bih Show Lou; Robert Hughes; Irene A. De Leon; Peg Davis; Terrence J. Gillespie; Marek Romanowski; Zhu Xiaoyun; Aleksandra Misicka; Andrzej W. Lipkowski; Frank Porreca; Thomas P. Davis; Henry I. Yamamura; David F. O'Brien; Victor J. Hruby

doi:10.1016/S0960-894X(98)00065-1

Modifications op the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide

Guigen Li
, W. Haq
, Li Xiang
, Bih Show Lou
, Robert Hughes
, Irene A. De Leon
, Peg Davis
, Terrence J. Gillespie
, Marek Romanowski
, Zhu Xiaoyun
, Aleksandra Misicka
, Andrzej W. Lipkowski
, Frank Porreca
, Thomas P. Davis
, Henry I. Yamamura
, David F. O'Brien
, Victor J. Hruby^*

^*Corresponding author for this work

University of Arizona

Research output: Contribution to journal › Journal Article › peer-review

27 Scopus citations

Abstract

Modifications of 4,4' residues of Biphalin have resulted in greater binding selectivity and biological potency for the μ opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a β-branched unusual amino acids.

Original language	English
Pages (from-to)	555-560
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/S0960-894X(98)00065-1
State	Published - 03 03 1998
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/S0960-894X(98)00065-1

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Li, G., Haq, W., Xiang, L., Lou, B. S., Hughes, R., De Leon, I. A., Davis, P., Gillespie, T. J., Romanowski, M., Xiaoyun, Z., Misicka, A., Lipkowski, A. W., Porreca, F., Davis, T. P., Yamamura, H. I., O'Brien, D. F., & Hruby, V. J. (1998). Modifications op the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide. Bioorganic and Medicinal Chemistry Letters, 8(5), 555-560. https://doi.org/10.1016/S0960-894X(98)00065-1

@article{de8ddb9834fe43449600cf38531de156,

title = "Modifications op the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide",

abstract = "Modifications of 4,4' residues of Biphalin have resulted in greater binding selectivity and biological potency for the μ opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a β-branched unusual amino acids.",

author = "Guigen Li and W. Haq and Li Xiang and Lou, \{Bih Show\} and Robert Hughes and \{De Leon\}, \{Irene A.\} and Peg Davis and Gillespie, \{Terrence J.\} and Marek Romanowski and Zhu Xiaoyun and Aleksandra Misicka and Lipkowski, \{Andrzej W.\} and Frank Porreca and Davis, \{Thomas P.\} and Yamamura, \{Henry I.\} and O'Brien, \{David F.\} and Hruby, \{Victor J.\}",

year = "1998",

month = mar,

day = "3",

doi = "10.1016/S0960-894X(98)00065-1",

language = "英语",

volume = "8",

pages = "555--560",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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}

Li, G, Haq, W, Xiang, L, Lou, BS, Hughes, R, De Leon, IA, Davis, P, Gillespie, TJ, Romanowski, M, Xiaoyun, Z, Misicka, A, Lipkowski, AW, Porreca, F, Davis, TP, Yamamura, HI, O'Brien, DF & Hruby, VJ 1998, 'Modifications op the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide', Bioorganic and Medicinal Chemistry Letters, vol. 8, no. 5, pp. 555-560. https://doi.org/10.1016/S0960-894X(98)00065-1

TY - JOUR

T1 - Modifications op the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide

AU - Li, Guigen

AU - Haq, W.

AU - Xiang, Li

AU - Lou, Bih Show

AU - Hughes, Robert

AU - De Leon, Irene A.

AU - Davis, Peg

AU - Gillespie, Terrence J.

AU - Romanowski, Marek

AU - Xiaoyun, Zhu

AU - Misicka, Aleksandra

AU - Lipkowski, Andrzej W.

AU - Porreca, Frank

AU - Davis, Thomas P.

AU - Yamamura, Henry I.

AU - O'Brien, David F.

AU - Hruby, Victor J.

PY - 1998/3/3

Y1 - 1998/3/3

N2 - Modifications of 4,4' residues of Biphalin have resulted in greater binding selectivity and biological potency for the μ opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a β-branched unusual amino acids.

AB - Modifications of 4,4' residues of Biphalin have resulted in greater binding selectivity and biological potency for the μ opioid receptor. A higher partition coefficient across the phospholipid bilayer membrane has been achieved by using a β-branched unusual amino acids.

UR - https://www.scopus.com/pages/publications/0032477944

U2 - 10.1016/S0960-894X(98)00065-1

DO - 10.1016/S0960-894X(98)00065-1

M3 - 文章

C2 - 9871617

AN - SCOPUS:0032477944

SN - 0960-894X

VL - 8

SP - 555

EP - 560

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 5

ER -

Modifications op the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide

Abstract

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