TY - JOUR
T1 - Modulating motor cortical oscillation with coordinated reset multifocal transcranial magnetic stimulation
AU - Chen, Kai Hsiang Stanley
AU - Hung, Tzu Kang
AU - Chikara, Rupesh Kumar
AU - Kuo, Yu Ting
AU - Liu, Yi Ping
AU - Dong, Yan Siou
AU - Wu, Yih Ru
AU - Ko, Li Wei
AU - Huang, Ying Zu
AU - Chen, Robert
PY - 2023/5/1
Y1 - 2023/5/1
N2 - According to the theory of coordinated reset (CR) stimulation, multifocal bursts of stimuli delivered in a random order with a specific interval may reduce the resonance power of the oscillatory generator in the epicenter. We develop a noninvasive coordinated multifocal burst stimulation (COMBS) with three repetitive transcranial stimulation machines based on CR theory to modulate the target frequency in the primary motor cortex and to assess its effect on motor cortical excitability in separate experiments. Electroencephalography and electromyography were recorded in 16 healthy participants during a finger-tapping task, both before and after the intervention. The resting oscillatory power at the targeted frequency was not changed by COMBS. α-Band power was increased in both preparation and movement stages and the low β-band power was increased in the movement stage of the finger tapping task. The extent of low β-band event-related desynchronization was reduced by COMBS. There were no changes in reaction time, but there was a trend for a reduced error rate after COMBS. In another 14 healthy participants, there were no significant changes in cortical excitability before and after COMBS measured by rest motor threshold, short interval intracortical inhibition, short interval intracortical facilitation, and cortical silent period. The result indicates that COMBS may modify the cortical oscillatory power and its perturbation within specific movement stage.NEW & NOTEWORTHY This is the first study, to our knowledge, to apply coordinated reset (CR) neuromodulation to the motor cortex with three repetitive transcranial magnetic stimulation (rTMS) stimulators to assess its effect on cortical oscillation. The results revealed enhancement of α-band power specifically in preparation and movement stages and low β-band power in the movement stage of a motor task. It postulated that CR stimulation may modify the motor cortical oscillation in the specific movement stages.
AB - According to the theory of coordinated reset (CR) stimulation, multifocal bursts of stimuli delivered in a random order with a specific interval may reduce the resonance power of the oscillatory generator in the epicenter. We develop a noninvasive coordinated multifocal burst stimulation (COMBS) with three repetitive transcranial stimulation machines based on CR theory to modulate the target frequency in the primary motor cortex and to assess its effect on motor cortical excitability in separate experiments. Electroencephalography and electromyography were recorded in 16 healthy participants during a finger-tapping task, both before and after the intervention. The resting oscillatory power at the targeted frequency was not changed by COMBS. α-Band power was increased in both preparation and movement stages and the low β-band power was increased in the movement stage of the finger tapping task. The extent of low β-band event-related desynchronization was reduced by COMBS. There were no changes in reaction time, but there was a trend for a reduced error rate after COMBS. In another 14 healthy participants, there were no significant changes in cortical excitability before and after COMBS measured by rest motor threshold, short interval intracortical inhibition, short interval intracortical facilitation, and cortical silent period. The result indicates that COMBS may modify the cortical oscillatory power and its perturbation within specific movement stage.NEW & NOTEWORTHY This is the first study, to our knowledge, to apply coordinated reset (CR) neuromodulation to the motor cortex with three repetitive transcranial magnetic stimulation (rTMS) stimulators to assess its effect on cortical oscillation. The results revealed enhancement of α-band power specifically in preparation and movement stages and low β-band power in the movement stage of a motor task. It postulated that CR stimulation may modify the motor cortical oscillation in the specific movement stages.
KW - coordinated reset
KW - event-related desynchronization
KW - low beta oscillation
KW - motor cortical excitability
KW - repetitive transcranial magnetic stimulation (rTMS)
UR - http://www.scopus.com/inward/record.url?scp=85153803043&partnerID=8YFLogxK
U2 - 10.1152/jn.00227.2022
DO - 10.1152/jn.00227.2022
M3 - 文章
C2 - 36922160
AN - SCOPUS:85153803043
SN - 0022-3077
VL - 129
SP - 1061
EP - 1071
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
IS - 5
ER -