Molecular genetics of renal cell carcinoma

Tomoya Fukawa; Nicholas Shannon; Dachuan Huang; Jing Tan; Xiaosai Yao; Steven G. Rozen; Patrick Tan; Bin T. Teh

doi:10.1007/978-4-431-55531-5_3

Molecular genetics of renal cell carcinoma

Tomoya Fukawa^*
, Nicholas Shannon
, Dachuan Huang
, Jing Tan
, Xiaosai Yao
, Steven G. Rozen
, Patrick Tan
, Bin T. Teh

^*Corresponding author for this work

National Cancer Centre
Duke-NUS Medical School
Tokushima University
Agency for Science, Technology and Research, Singapore
Singapore Health Services
National University of Singapore

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

In the last decade, from the early large-scale multigene profiling using traditional Sanger sequencing to the more recent next-generation whole-exome and whole-genome sequencing, the genomic landscapes of renal cell carcinoma (RCC), consisting mainly of clear-cell, papillary (1 and 2), and chromophobe subtypes, have been characterized. This genomic information, coupled with DNA methylation, has shed light on the molecular biology of RCC and created tremendous opportunities for future research that hopefully will lead to improvement in diagnosis, prognosis, treatment, and prevention of RCC. This chapter will summarize the most recent genomic and DNA methylation profiles of these three subtypes of RCC and highlight the major biological pathways involved and their clinical relevance.

Original language	English
Title of host publication	Renal Cell Carcinoma
Subtitle of host publication	Molecular Features and Treatment Updates
Publisher	Springer Japan
Pages	83-103
Number of pages	21
ISBN (Electronic)	9784431555315
ISBN (Print)	9784431555308
DOIs	https://doi.org/10.1007/978-4-431-55531-5_3
State	Published - 01 01 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer Japan KK 2017. All rights are reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Genomics
RCC

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10.1007/978-4-431-55531-5_3

Cite this

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title = "Molecular genetics of renal cell carcinoma",

abstract = "In the last decade, from the early large-scale multigene profiling using traditional Sanger sequencing to the more recent next-generation whole-exome and whole-genome sequencing, the genomic landscapes of renal cell carcinoma (RCC), consisting mainly of clear-cell, papillary (1 and 2), and chromophobe subtypes, have been characterized. This genomic information, coupled with DNA methylation, has shed light on the molecular biology of RCC and created tremendous opportunities for future research that hopefully will lead to improvement in diagnosis, prognosis, treatment, and prevention of RCC. This chapter will summarize the most recent genomic and DNA methylation profiles of these three subtypes of RCC and highlight the major biological pathways involved and their clinical relevance.",

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author = "Tomoya Fukawa and Nicholas Shannon and Dachuan Huang and Jing Tan and Xiaosai Yao and Rozen, \{Steven G.\} and Patrick Tan and Teh, \{Bin T.\}",

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doi = "10.1007/978-4-431-55531-5\_3",

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T1 - Molecular genetics of renal cell carcinoma

AU - Fukawa, Tomoya

AU - Shannon, Nicholas

AU - Huang, Dachuan

AU - Tan, Jing

AU - Yao, Xiaosai

AU - Rozen, Steven G.

AU - Tan, Patrick

AU - Teh, Bin T.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - In the last decade, from the early large-scale multigene profiling using traditional Sanger sequencing to the more recent next-generation whole-exome and whole-genome sequencing, the genomic landscapes of renal cell carcinoma (RCC), consisting mainly of clear-cell, papillary (1 and 2), and chromophobe subtypes, have been characterized. This genomic information, coupled with DNA methylation, has shed light on the molecular biology of RCC and created tremendous opportunities for future research that hopefully will lead to improvement in diagnosis, prognosis, treatment, and prevention of RCC. This chapter will summarize the most recent genomic and DNA methylation profiles of these three subtypes of RCC and highlight the major biological pathways involved and their clinical relevance.

AB - In the last decade, from the early large-scale multigene profiling using traditional Sanger sequencing to the more recent next-generation whole-exome and whole-genome sequencing, the genomic landscapes of renal cell carcinoma (RCC), consisting mainly of clear-cell, papillary (1 and 2), and chromophobe subtypes, have been characterized. This genomic information, coupled with DNA methylation, has shed light on the molecular biology of RCC and created tremendous opportunities for future research that hopefully will lead to improvement in diagnosis, prognosis, treatment, and prevention of RCC. This chapter will summarize the most recent genomic and DNA methylation profiles of these three subtypes of RCC and highlight the major biological pathways involved and their clinical relevance.

KW - Cancer

KW - Genomics

KW - RCC

UR - https://www.scopus.com/pages/publications/85019479681

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DO - 10.1007/978-4-431-55531-5_3

M3 - 章节

AN - SCOPUS:85019479681

SN - 9784431555308

SP - 83

EP - 103

BT - Renal Cell Carcinoma

PB - Springer Japan

ER -

Molecular genetics of renal cell carcinoma

Abstract

Bibliographical note

UN SDGs

Keywords

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