Abstract
In chloralose-urethane-anesthetized cats, intravertebral injection of morphine (1,2 and 4 mg/kg) promoted a drastic suppression of the bradycardia elicited by stimulating the medullary gigantocelular reticular nucleus (GRN). The degree of blockadge of GRN-induced cardioinhibition was directly dependent upon the dose of morphine and inversely related to the reticular stimulus train intensity and pulse frequency. The possibility that the GRM may be a site of action for morphine in its production of hypotension and bradycardia was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 205-209 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 214 |
| Issue number | 1 |
| DOIs | |
| State | Published - 09 06 1981 |
| Externally published | Yes |
Keywords
- bradycardia
- cat
- gigantocellular reticular nucleus
- hypotension
- morphine