Moving-source elastic wave reconstruction for high-resolution optical coherence elastography

Bao Yu Hsieh*, Shaozhen Song, Thu Mai Nguyen, Soon Joon Yoon, Tueng T. Shen, Ruikang K. Wang, Matthew O'Donnell

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

6 Scopus citations


Optical coherence tomography (OCT)-based elasticity imaging can map soft tissue elasticity based on speckle-tracking of elastic wave propagation using highly sensitive phase measurements of OCT signals. Using a fixed elastic wave source and moving detection, current imaging sequences have difficulty in reconstructing tissue elasticity within speckle-free regions, for example, within the crystalline lens of the eye. We present a moving acoustic radiation force imaging sequence to reconstruct elastic properties within a speckle-free region by tracking elastic wave propagation from multiple laterally moving sources across the field of view. We demonstrate the proposed strategy using heterogeneous and partial speckle-free tissue-mimicking phantoms. Harder inclusions within the speckle-free region can be detected, and the contrast-to-noise ratio slightly enhanced compared to current OCE imaging sequences. The results suggest that a moving source approach may be appropriate for OCE studies within the large speckle-free regions of the crystalline lens.

Original languageEnglish
Article number116006
JournalJournal of Biomedical Optics
Issue number11
StatePublished - 01 11 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 The Authors.


  • Presbyopia
  • acoustic radiation force
  • crystalline lens
  • elasticity imaging
  • moving-source reconstruction
  • optical coherence elasticity imaging


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