MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan

Chih Ching Yeh, Ling Ling Hsieh, Reiping Tang, Chung Rong Chang-Chieh, Fung Chang Sung*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

41 Scopus citations


This hospital-based case-control study examined whether polymorphic DNA repair genes: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, play a role in the susceptibility to colorectal cancer. We genotyped these polymorphisms for 727 newly diagnosed colorectal adenocarcinoma cases and 736 age and sex matched healthy controls in Taiwan. Although the colorectal cancer risk was not significantly associated with these genes, the risk was significantly elevated in younger subjects (≤60 years) with the XRCC1 399Arg/Arg genotype compared to those with XRCC1 399Gln allele (OR=1.46, 95% CI=1.06-2.99, P=0.02). The stratified analysis showed that XRCC3 interacted with meat consumption (P for interaction=0.02), but was limited to the low meat consumption (OR=2.34, 95% CI=1.28-4.29). Our results suggest that the XRCC1 Arg399Gln polymorphism may contribute to the risk of early-onset colorectal cancer and the XRCC3 Thr241Met polymorphism may modify the risk for meat-associated colorectal cancer.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalCancer Letters
Issue number2
StatePublished - 28 06 2005


  • Colorectal cancer
  • Diet
  • Polymorphisms
  • XPD
  • XRCC1
  • XRCC3


Dive into the research topics of 'MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan'. Together they form a unique fingerprint.

Cite this