Multicentric plasma cell Castleman's disease associated with POEMS syndrome: CT findings

Castleman's disease (CD) is a rare lymphoproliferative disorder of unknown cause. In even rarer circumstances, it can be associated with POEMS (peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome. We report a case of multicentric plasma cell CD with POEMS syndrome, who presented with inguinal masses and lower extremity weakness for years. Computed tomography (CT) demonstrated widespread enlarged lymph nodes with homogenous enhancement, as well as splenomegaly and gynecomastia. Recognition of the CT findings in patients with appropriate clinical settings is helpful in suggesting the diagnosis of multicentric CD associated with POEMS syndrome.