Multiplexed immunoglobulin e sensitization in relation to exhaled nitric oxide in a population sample of children

Tsung Chieh Yao; H. J. Tsai; Y. L. Tu; S. W. Chang; M. C. Hua; S. L. Liao; M. H. Tsai; C. Y. Chiu; S. H. Lai; K. W. Yeh; Jing Long Huang

doi:10.1111/all.12378

Multiplexed immunoglobulin e sensitization in relation to exhaled nitric oxide in a population sample of children

Tsung Chieh Yao^*, H. J. Tsai, Y. L. Tu, S. W. Chang, M. C. Hua, S. L. Liao, M. H. Tsai, C. Y. Chiu, S. H. Lai, K. W. Yeh, Jing Long Huang

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.

Original language	English
Pages (from-to)	678-682
Number of pages	5
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	69
Issue number	5
DOIs	https://doi.org/10.1111/all.12378
State	Published - 2014

Keywords

Asian
allergic sensitization
atopy
children
exhaled nitric oxide

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Yao, T. C., Tsai, H. J., Tu, Y. L., Chang, S. W., Hua, M. C., Liao, S. L., Tsai, M. H., Chiu, C. Y., Lai, S. H., Yeh, K. W., & Huang, J. L. (2014). Multiplexed immunoglobulin e sensitization in relation to exhaled nitric oxide in a population sample of children. Allergy: European Journal of Allergy and Clinical Immunology, 69(5), 678-682. https://doi.org/10.1111/all.12378

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title = "Multiplexed immunoglobulin e sensitization in relation to exhaled nitric oxide in a population sample of children",

abstract = "This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.",

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author = "Yao, {Tsung Chieh} and Tsai, {H. J.} and Tu, {Y. L.} and Chang, {S. W.} and Hua, {M. C.} and Liao, {S. L.} and Tsai, {M. H.} and Chiu, {C. Y.} and Lai, {S. H.} and Yeh, {K. W.} and Huang, {Jing Long}",

year = "2014",

doi = "10.1111/all.12378",

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volume = "69",

pages = "678--682",

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AU - Yao, Tsung Chieh

AU - Tsai, H. J.

AU - Tu, Y. L.

AU - Chang, S. W.

AU - Hua, M. C.

AU - Liao, S. L.

AU - Tsai, M. H.

AU - Chiu, C. Y.

AU - Lai, S. H.

AU - Yeh, K. W.

AU - Huang, Jing Long

PY - 2014

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N2 - This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.

AB - This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.

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KW - allergic sensitization

KW - atopy

KW - children

KW - exhaled nitric oxide

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ER -

Multiplexed immunoglobulin e sensitization in relation to exhaled nitric oxide in a population sample of children

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Keywords

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