Myxoid liposarcoma with cartilaginous differentiation: Identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components

Yu Ching Wei, Chien Feng Li, Hock Liew Eng, Ming Chung Yeh, Ching Nan Lin, Hsuan Ying Huang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations

Abstract

Heterologous differentiation in adipocytic tumors is a rare phenomenon. Only 4 cases of myxoid liposarcoma (MLS) with cartilaginous differentiation were thus far reported without confirmatory molecular assays. We describe a primary MLS with chondroid differentiation that affected the left thigh of a 47-year-old man. Histologically, multiple sharply demarcated chondroid nodules were embedded among the classic MLS area. By reverse transcription-polymerase chain reaction, the identical type II TLS-CHOP fusion gene transcripts were detected in both the liposarcomatous and microdissected chondroid tumor cells. Our case confirms the actual existence of MLS with cartilaginous differentiation and the neoplastic nature of chondroid component.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalApplied Immunohistochemistry and Molecular Morphology
Volume15
Issue number4
DOIs
StatePublished - 12 2007
Externally publishedYes

Keywords

  • Cartilaginous metaplasia
  • Myxoid liposarcoma
  • TLS-CHOP

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