Nano-sized drug carrier for cancer therapy: Dose-toxicity relationship of PEG-PCL-PEG polymeric micelle on ICR mice

J. L. Jiang; N. V. Cuong; S. C. Jwo; M. F. Hsieh

doi:10.1007/978-3-642-13039-7_203

Nano-sized drug carrier for cancer therapy: Dose-toxicity relationship of PEG-PCL-PEG polymeric micelle on ICR mice

J. L. Jiang
, N. V. Cuong
, S. C. Jwo
, M. F. Hsieh

Chung Yuan Christian University
Chang Gung Memorial Hospital

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Amphiphilic polymeric nanoparticles garnered attention in pharmaceutical and medical fields because of its benefits of the sustained release, the extended circulation, the uptake by reticuloendothelial system in human body when used as the carrier of anti-cancer drugs. In the present study, we aimed to evaluate the biocompatibility of biodegradable triblock copolymer (PEG-PCL-PEG) used as the carrier of anti-cancer drugs. The synthesized PEG-PCL-PEG was synthesized and formed nano-sized micellar nanoparticles spontaneously in aqueous solution. The particle size was in the range of 40.2-85.3 nm. In-vitro hemolysis test indicated that 2.0 mg/mL micelle without drug loading caused no damage to red blood cells. In-vivo study on ICR mice displayed minor pathological response in liver and kidney of tested mice administrated intravenously 71.43 mg/kg nanoparticles. When the dose of nanoparticles increased to 91.95 mg/kg, both renal and liver toxicity was observed. This finding brings us further design of in-vivo study for loading anti-cancer drug, such as doxorubicin in the PEG-PCL-PEG carrier within a safe administration dose.

Original language	English
Title of host publication	XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010
Pages	804-807
Number of pages	4
DOIs	https://doi.org/10.1007/978-3-642-13039-7_203
State	Published - 2010
Externally published	Yes
Event	12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010 - Chalkidiki, Greece Duration: 27 05 2010 → 30 05 2010

Publication series

Name	IFMBE Proceedings
Volume	29
ISSN (Print)	1680-0737

Conference

Conference	12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010
Country/Territory	Greece
City	Chalkidiki
Period	27/05/10 → 30/05/10

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Amphiphilic polymer
Hemolysis
In-vivo Toxicity
Nanoparticles
Poly(ε-caprolactone)
Polyethylene glycol

Access to Document

10.1007/978-3-642-13039-7_203

Cite this

Jiang, J. L., Cuong, N. V., Jwo, S. C., & Hsieh, M. F. (2010). Nano-sized drug carrier for cancer therapy: Dose-toxicity relationship of PEG-PCL-PEG polymeric micelle on ICR mice. In XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010 (pp. 804-807). (IFMBE Proceedings; Vol. 29). https://doi.org/10.1007/978-3-642-13039-7_203

@inproceedings{3338722b79f248a0a14ddc55078e40af,

title = "Nano-sized drug carrier for cancer therapy: Dose-toxicity relationship of PEG-PCL-PEG polymeric micelle on ICR mice",

abstract = "Amphiphilic polymeric nanoparticles garnered attention in pharmaceutical and medical fields because of its benefits of the sustained release, the extended circulation, the uptake by reticuloendothelial system in human body when used as the carrier of anti-cancer drugs. In the present study, we aimed to evaluate the biocompatibility of biodegradable triblock copolymer (PEG-PCL-PEG) used as the carrier of anti-cancer drugs. The synthesized PEG-PCL-PEG was synthesized and formed nano-sized micellar nanoparticles spontaneously in aqueous solution. The particle size was in the range of 40.2-85.3 nm. In-vitro hemolysis test indicated that 2.0 mg/mL micelle without drug loading caused no damage to red blood cells. In-vivo study on ICR mice displayed minor pathological response in liver and kidney of tested mice administrated intravenously 71.43 mg/kg nanoparticles. When the dose of nanoparticles increased to 91.95 mg/kg, both renal and liver toxicity was observed. This finding brings us further design of in-vivo study for loading anti-cancer drug, such as doxorubicin in the PEG-PCL-PEG carrier within a safe administration dose.",

keywords = "Amphiphilic polymer, Hemolysis, In-vivo Toxicity, Nanoparticles, Poly(ε-caprolactone), Polyethylene glycol",

author = "Jiang, \{J. L.\} and Cuong, \{N. V.\} and Jwo, \{S. C.\} and Hsieh, \{M. F.\}",

year = "2010",

doi = "10.1007/978-3-642-13039-7\_203",

language = "英语",

isbn = "9783642130380",

series = "IFMBE Proceedings",

pages = "804--807",

booktitle = "XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010",

note = "12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010 ; Conference date: 27-05-2010 Through 30-05-2010",

}

Jiang, JL, Cuong, NV, Jwo, SC & Hsieh, MF 2010, Nano-sized drug carrier for cancer therapy: Dose-toxicity relationship of PEG-PCL-PEG polymeric micelle on ICR mice. in XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010. IFMBE Proceedings, vol. 29, pp. 804-807, 12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010, Chalkidiki, Greece, 27/05/10. https://doi.org/10.1007/978-3-642-13039-7_203

Nano-sized drug carrier for cancer therapy: Dose-toxicity relationship of PEG-PCL-PEG polymeric micelle on ICR mice. / Jiang, J. L.; Cuong, N. V.; Jwo, S. C. et al.
XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010. 2010. p. 804-807 (IFMBE Proceedings; Vol. 29).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Nano-sized drug carrier for cancer therapy

T2 - 12th Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2010

AU - Jiang, J. L.

AU - Cuong, N. V.

AU - Jwo, S. C.

AU - Hsieh, M. F.

PY - 2010

Y1 - 2010

N2 - Amphiphilic polymeric nanoparticles garnered attention in pharmaceutical and medical fields because of its benefits of the sustained release, the extended circulation, the uptake by reticuloendothelial system in human body when used as the carrier of anti-cancer drugs. In the present study, we aimed to evaluate the biocompatibility of biodegradable triblock copolymer (PEG-PCL-PEG) used as the carrier of anti-cancer drugs. The synthesized PEG-PCL-PEG was synthesized and formed nano-sized micellar nanoparticles spontaneously in aqueous solution. The particle size was in the range of 40.2-85.3 nm. In-vitro hemolysis test indicated that 2.0 mg/mL micelle without drug loading caused no damage to red blood cells. In-vivo study on ICR mice displayed minor pathological response in liver and kidney of tested mice administrated intravenously 71.43 mg/kg nanoparticles. When the dose of nanoparticles increased to 91.95 mg/kg, both renal and liver toxicity was observed. This finding brings us further design of in-vivo study for loading anti-cancer drug, such as doxorubicin in the PEG-PCL-PEG carrier within a safe administration dose.

AB - Amphiphilic polymeric nanoparticles garnered attention in pharmaceutical and medical fields because of its benefits of the sustained release, the extended circulation, the uptake by reticuloendothelial system in human body when used as the carrier of anti-cancer drugs. In the present study, we aimed to evaluate the biocompatibility of biodegradable triblock copolymer (PEG-PCL-PEG) used as the carrier of anti-cancer drugs. The synthesized PEG-PCL-PEG was synthesized and formed nano-sized micellar nanoparticles spontaneously in aqueous solution. The particle size was in the range of 40.2-85.3 nm. In-vitro hemolysis test indicated that 2.0 mg/mL micelle without drug loading caused no damage to red blood cells. In-vivo study on ICR mice displayed minor pathological response in liver and kidney of tested mice administrated intravenously 71.43 mg/kg nanoparticles. When the dose of nanoparticles increased to 91.95 mg/kg, both renal and liver toxicity was observed. This finding brings us further design of in-vivo study for loading anti-cancer drug, such as doxorubicin in the PEG-PCL-PEG carrier within a safe administration dose.

KW - Amphiphilic polymer

KW - Hemolysis

KW - In-vivo Toxicity

KW - Nanoparticles

KW - Poly(ε-caprolactone)

KW - Polyethylene glycol

UR - https://www.scopus.com/pages/publications/77957596275

U2 - 10.1007/978-3-642-13039-7_203

DO - 10.1007/978-3-642-13039-7_203

M3 - 会议稿件

AN - SCOPUS:77957596275

SN - 9783642130380

T3 - IFMBE Proceedings

SP - 804

EP - 807

BT - XII Mediterranean Conference on Medical and Biological Engineering and Computing 2010, MEDICON 2010

Y2 - 27 May 2010 through 30 May 2010

ER -

Nano-sized drug carrier for cancer therapy: Dose-toxicity relationship of PEG-PCL-PEG polymeric micelle on ICR mice

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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