@inproceedings{71abb5ae327b494a8ef0b6e72e801ec1,
title = "Nanoparticles-based electrochemical biosensor for single bacterium detection by redox signal amplification",
abstract = "In this work, we report a portable mierofluidie chip based on Si-Porous-Pt MSNs(Mesoporous Silica Nanoparticles) -enhanced electrochemical detection for single-bacteria diognostic. The possibility of single-bacteria detection is realized here by using electroactivc molecules modified on Si-Porous-Pt MSNs(Mcsoporous Silica Nanoparticles) to detect and differentiate Staphylococcus aureus and Pseudomonas aeruginosa. The detection limit of these two electroactivc molecules is near femtomolar (1 pM) when immobilized on Si-Porous-Pt MSNs(Mesoporous Silica Nanoparticles), and the minima amounts of gold NPs required in the detection is around thousands (103 particle/μl). A concentration of couples whole bacteria (<10 cells/μ1) is detected by CV measurements. The liner detection limit conccntion is form 1- 1000 cells/μl. The results showed that the portable biochip system has great potential as a device for single -particle or possibly even single-organism detection.",
keywords = "Redox signal amplification, Si-Porous-Pt MSNs(mcsoporous silica nanoparticlcs), Singlc bacteria detection",
author = "Lu, {Chih Shuan} and Wen, {Po Chao} and Chang, {Hwan You} and Tseng, {Fan Gang}",
year = "2013",
language = "英语",
isbn = "9781632666246",
series = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
publisher = "Chemical and Biological Microsystems Society",
pages = "239--241",
booktitle = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013",
note = "17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 ; Conference date: 27-10-2013 Through 31-10-2013",
}