Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils

Lin Yang Cheng, Hsiang Ruei Liao, Li Chai Chen, Shih Wei Wang, Yueh Hsiung Kuo, Mei Ing Chung*, Jih Jung Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3 − 20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-O-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50 ≤ 28.84 μM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalFitoterapia
Volume117
DOIs
StatePublished - 01 03 2017

Bibliographical note

Publisher Copyright:
© 2016

Keywords

  • Anti-inflammatory activity
  • Bombacaceae
  • Naphthofuranone
  • Pachira aquatica
  • Structure elucidation

Fingerprint

Dive into the research topics of 'Naphthofuranone derivatives and other constituents from Pachira aquatica with inhibitory activity on superoxide anion generation by neutrophils'. Together they form a unique fingerprint.

Cite this