Abstract
Two new naphthofuranone derivatives, 11-hydroxy-2-O-methylhibiscolactone A (1) and O-methylhibiscone D (2), have been isolated from the stems of Pachira aquatica, together with 18 known compounds (3 − 20). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 11-hydroxy-2-O-methylhibiscolactone A (1), isohemigossylic acid lactone-7-methyl ether (4), gmelofuran (6), and 5-hydroxyauranetin (8) exhibited inhibition (IC50 ≤ 28.84 μM) of superoxide anion generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP).
Original language | English |
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Pages (from-to) | 16-21 |
Number of pages | 6 |
Journal | Fitoterapia |
Volume | 117 |
DOIs | |
State | Published - 01 03 2017 |
Bibliographical note
Publisher Copyright:© 2016
Keywords
- Anti-inflammatory activity
- Bombacaceae
- Naphthofuranone
- Pachira aquatica
- Structure elucidation