Naphthoquinone esters from the root of Rhinacanthus nasutus

Tian Shung Wu*, Hua Chun Hsu, Pei Lin Wu, Yann Lii Leu, Yu Yi Chan, Ching Yuh Chern, Mou Yung Yeh, Hsien Ju Tien

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

55 Scopus citations

Abstract

Reinvestigation of the root of Rhinacanthus nasutus afforded, in addition to rhinacanthin-A to -D reported previously, two new dimethyldihydropyranonaphthoquinone esters (5, 6) and eight new 2-hydroxy- 1,4-naphthoquinone esters (7-14) were isolated. The stereochemistry of rhinacanthin-A was determined as the R configuration. Compounds rhinacanthin- G to -N, belong to a class of 2-hydroxy-3-(3-hydroxy-2,2-dimethylpropyl)- 1,4-naphthoquinone esters, and so far have been isolated only in this plant. Their biosynthesis is also discussed.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume46
Issue number3
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Acanthaceae
  • Naphthoquinone ester
  • Rhinacanthus nasutus

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