National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Yu-chia Hsieh, Pen Yi Lin, Cherng-Hsun Chiu, Yhu-Chering Huang, Kuang Yi Chang, Chun Hsing Liao, Nan Chang Chiu, Yin Ching Chuang, Po Yen Chen, Shan Chwen Chang, Jien-Wei Liu, Muh Yong Yen, Jen Hsien Wang, Cheng Yi Liu, Tzou Yien Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

96 Scopus citations

Abstract

We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ≤5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ≤5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed.

Original languageEnglish
Pages (from-to)5513-5518
Number of pages6
JournalVaccine
Volume27
Issue number40
DOIs
StatePublished - 04 09 2009

Keywords

  • Invasive pneumococcal diseases
  • Invasive potential
  • Serotype 19A

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