Natural clovanes from the gorgonian coral rumphella antipathies

Hsu Ming Chung, Wei Hsien Wang, Tsong Long Hwang, Yang Chang Wu, Ping Jyun Sung

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

Three natural clovane-related sesquiterpenoids, 2β-acetoxyclovan- 9α-ol (1), 9α-acetoxyclovan-2β-ol (2) and clovan-2β, 9β-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

Original languageEnglish
Pages (from-to)1037-1040
Number of pages4
JournalNatural Product Communications
Volume8
Issue number8
DOIs
StatePublished - 08 2013

Keywords

  • Anti-inflammatory
  • Clovane
  • Elastase
  • Rumphella antipathies
  • Superoxide anion

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