Natural clovanes from the gorgonian coral rumphella antipathies

Hsu Ming Chung; Wei Hsien Wang; Tsong Long Hwang; Yang Chang Wu; Ping Jyun Sung

doi:10.1177/1934578x1300800801

Natural clovanes from the gorgonian coral rumphella antipathies

Hsu Ming Chung
, Wei Hsien Wang
, Tsong Long Hwang
, Yang Chang Wu
, Ping Jyun Sung

School of Traditional Chinese Medicine

National Sun Yat-sen University
National Museum of Marine Biology and Aquarium, Taiwan
China Medical University Taichung
National Dong Hwa University
Kaohsiung Medical University

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Three natural clovane-related sesquiterpenoids, 2β-acetoxyclovan- 9α-ol (1), 9α-acetoxyclovan-2β-ol (2) and clovan-2β, 9β-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

Original language	English
Pages (from-to)	1037-1040
Number of pages	4
Journal	Natural Product Communications
Volume	8
Issue number	8
DOIs	https://doi.org/10.1177/1934578x1300800801
State	Published - 08 2013

Keywords

Anti-inflammatory
Clovane
Elastase
Rumphella antipathies
Superoxide anion

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10.1177/1934578x1300800801

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title = "Natural clovanes from the gorgonian coral rumphella antipathies",

abstract = "Three natural clovane-related sesquiterpenoids, 2β-acetoxyclovan- 9α-ol (1), 9α-acetoxyclovan-2β-ol (2) and clovan-2β, 9β-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.",

keywords = "Anti-inflammatory, Clovane, Elastase, Rumphella antipathies, Superoxide anion",

author = "Chung, \{Hsu Ming\} and Wang, \{Wei Hsien\} and Hwang, \{Tsong Long\} and Wu, \{Yang Chang\} and Sung, \{Ping Jyun\}",

year = "2013",

month = aug,

doi = "10.1177/1934578x1300800801",

language = "英语",

volume = "8",

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T1 - Natural clovanes from the gorgonian coral rumphella antipathies

AU - Chung, Hsu Ming

AU - Wang, Wei Hsien

AU - Hwang, Tsong Long

AU - Wu, Yang Chang

AU - Sung, Ping Jyun

PY - 2013/8

Y1 - 2013/8

N2 - Three natural clovane-related sesquiterpenoids, 2β-acetoxyclovan- 9α-ol (1), 9α-acetoxyclovan-2β-ol (2) and clovan-2β, 9β-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

AB - Three natural clovane-related sesquiterpenoids, 2β-acetoxyclovan- 9α-ol (1), 9α-acetoxyclovan-2β-ol (2) and clovan-2β, 9β-diol (3), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1-3 were elucidated by spectroscopic methods and by comparison of the spectral data with those of known clovane analogues. This is the first time that clovanes 1-3 have been isolated from a natural source. Clovanes 1 and 2 displayed inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.

KW - Anti-inflammatory

KW - Clovane

KW - Elastase

KW - Rumphella antipathies

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/84883206875

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DO - 10.1177/1934578x1300800801

M3 - 文章

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AN - SCOPUS:84883206875

SN - 1934-578X

VL - 8

SP - 1037

EP - 1040

JO - Natural Product Communications

JF - Natural Product Communications

IS - 8

ER -

Natural clovanes from the gorgonian coral rumphella antipathies

Abstract

Keywords

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