Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species

Shu Yen Fang; Sheng Yuan Chen; You Ying Chen; Tsu Jen Kuo; Zhi Hong Wen; Yu Hsin Chen; Tsong Long Hwang; Ping Jyun Sung

doi:10.1177/1934578X211033735

Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species

Shu Yen Fang
, Sheng Yuan Chen
, You Ying Chen
, Tsu Jen Kuo
, Zhi Hong Wen
, Yu Hsin Chen
, Tsong Long Hwang
, Ping Jyun Sung^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Chang Gung University
Kaohsiung Armed Forces General Hospital
National Sun Yat-sen University
National Museum of Marine Biology and Aquarium, Taiwan
Chung Shan Medical University
China Medical University Taichung
Kaohsiung Medical University
Fu Jen Catholic University

Research output: Contribution to journal › Journal Article › peer-review

10 Scopus citations

Abstract

A new natural indole, vibrindole B (1), together with known analogs, vibrindole A (2), trisindoline (3), norharmane (4), and 3-(hydroxyacetyl)indole (5), produced by the bacterium Pseudovibrio denitrificans P81, were isolated from a sponge, Aaptos species. The structures of indoles 1 to 5 were established by spectroscopic methods. The proposed biosynthetic pathway of 1 to 5 is also discussed, starting from tryptophan. Moreover, indoles 1 to 3 were found to exhibit cytotoxicity toward T24 tumor cells with IC₅₀ values of 1.71 ± 0.11, 4.53 ± 0.14, and 2.26 ± 0.26 µM, respectively.

Original language	English
Journal	Natural Product Communications
Volume	16
Issue number	9
DOIs	https://doi.org/10.1177/1934578X211033735
State	Published - 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021.

Keywords

Aaptos
Pseudovibrio
cytotoxicity
sponge
vibrindole

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10.1177/1934578X211033735

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title = "Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species",

abstract = "A new natural indole, vibrindole B (1), together with known analogs, vibrindole A (2), trisindoline (3), norharmane (4), and 3-(hydroxyacetyl)indole (5), produced by the bacterium Pseudovibrio denitrificans P81, were isolated from a sponge, Aaptos species. The structures of indoles 1 to 5 were established by spectroscopic methods. The proposed biosynthetic pathway of 1 to 5 is also discussed, starting from tryptophan. Moreover, indoles 1 to 3 were found to exhibit cytotoxicity toward T24 tumor cells with IC50 values of 1.71 ± 0.11, 4.53 ± 0.14, and 2.26 ± 0.26 µM, respectively.",

keywords = "Aaptos, Pseudovibrio, cytotoxicity, sponge, vibrindole",

author = "Fang, \{Shu Yen\} and Chen, \{Sheng Yuan\} and Chen, \{You Ying\} and Kuo, \{Tsu Jen\} and Wen, \{Zhi Hong\} and Chen, \{Yu Hsin\} and Hwang, \{Tsong Long\} and Sung, \{Ping Jyun\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021.",

year = "2021",

doi = "10.1177/1934578X211033735",

language = "英语",

volume = "16",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "9",

}

TY - JOUR

T1 - Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species

AU - Fang, Shu Yen

AU - Chen, Sheng Yuan

AU - Chen, You Ying

AU - Kuo, Tsu Jen

AU - Wen, Zhi Hong

AU - Chen, Yu Hsin

AU - Hwang, Tsong Long

AU - Sung, Ping Jyun

PY - 2021

Y1 - 2021

N2 - A new natural indole, vibrindole B (1), together with known analogs, vibrindole A (2), trisindoline (3), norharmane (4), and 3-(hydroxyacetyl)indole (5), produced by the bacterium Pseudovibrio denitrificans P81, were isolated from a sponge, Aaptos species. The structures of indoles 1 to 5 were established by spectroscopic methods. The proposed biosynthetic pathway of 1 to 5 is also discussed, starting from tryptophan. Moreover, indoles 1 to 3 were found to exhibit cytotoxicity toward T24 tumor cells with IC50 values of 1.71 ± 0.11, 4.53 ± 0.14, and 2.26 ± 0.26 µM, respectively.

AB - A new natural indole, vibrindole B (1), together with known analogs, vibrindole A (2), trisindoline (3), norharmane (4), and 3-(hydroxyacetyl)indole (5), produced by the bacterium Pseudovibrio denitrificans P81, were isolated from a sponge, Aaptos species. The structures of indoles 1 to 5 were established by spectroscopic methods. The proposed biosynthetic pathway of 1 to 5 is also discussed, starting from tryptophan. Moreover, indoles 1 to 3 were found to exhibit cytotoxicity toward T24 tumor cells with IC50 values of 1.71 ± 0.11, 4.53 ± 0.14, and 2.26 ± 0.26 µM, respectively.

KW - Aaptos

KW - Pseudovibrio

KW - cytotoxicity

KW - sponge

KW - vibrindole

UR - https://www.scopus.com/pages/publications/85115998414

U2 - 10.1177/1934578X211033735

DO - 10.1177/1934578X211033735

M3 - 文章

AN - SCOPUS:85115998414

SN - 1934-578X

VL - 16

JO - Natural Product Communications

JF - Natural Product Communications

IS - 9

ER -

Natural Indoles From the Bacterium Pseudovibrio denitrificans P81 Isolated From a Marine Sponge, Aaptos Species

Abstract

Bibliographical note

Keywords

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