Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder

R.-F. Tzang; Y.-C. Wang; C.-B. Yeh; C.-D. Hsu; H.-Y. Liang; P.-C. Yang; H.-J. Liu; Yi-Shun Huang; H. Cheng; Y.-C. Hsu; S.-I. Liu; C.-H. Pan; Y.-F. Huang; C.-F. Huang; Y.-Y. Wu; Y.-H. Huang; H.-C. Liu; H.-L. Chang

doi:10.1111/j.1440-1819.2011.02289.x

Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder

R.-F. Tzang
, Y.-C. Wang
, C.-B. Yeh
, C.-D. Hsu
, H.-Y. Liang
, P.-C. Yang
, H.-J. Liu
, Yi-Shun Huang
, H. Cheng
, Y.-C. Hsu
, S.-I. Liu
, C.-H. Pan
, Y.-F. Huang
, C.-F. Huang
, Y.-Y. Wu
, Y.-H. Huang
, H.-C. Liu
, H.-L. Chang

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Aim: To determine the differences in the remission rate, recovery rate, functional improvement, and treatment adherence related to treatment with short-acting immediate-release methylphenidate (IR-MPH) and long-acting osmotic-release oral system-methylphenidate (OROS-MPH) in a naturalistic setting among Taiwanese children with attention-deficit-hyperactivity disorder (ADHD). Methods: A total of 757 children with ADHD, aged 6-18 years, was evaluated using the following in order determine functional improvement and treatment adherence: the Chinese version of the Swanson, Nolan, and Pelham, version IV scale (SNAP-IV-C), Clinical Global Impression-ADHD-Severity (CGI-S) to measure remission and recovery rates, the Chinese version of the Social Adjustment Inventory for Children and Adolescents (CSAICA), and caregiver's satisfaction rate, treatment adherence, and frequency of adverse effects. Results: According to the SNAP-IV-C scores, the remission rate was 30.72%, and the recovery rate was 16.38%. Compared to short-acting IR-MPH, OROS-MPH was associated with greater functional improvement and treatment adherence among children with ADHD. Conclusion: OROS-MPH treatment at the adequate dosage can achieve higher remission and recovery rates, produce greater functional improvement, and result in better treatment adherence than IR-MPH treatment. © 2012 Japanese Society of Psychiatry and Neurology.

Original language	American English
Pages (from-to)	53-63
Journal	Psychiatry and Clinical Neurosciences
Volume	66
Issue number	1
DOIs	https://doi.org/10.1111/j.1440-1819.2011.02289.x
State	Published - 2012

Keywords

OROS-MPH
attention-deficit-hyperactivity disorder
functionality
recovery rate
remission rate

Access to Document

10.1111/j.1440-1819.2011.02289.x

Cite this

Tzang, R.-F., Wang, Y.-C., Yeh, C.-B., Hsu, C.-D., Liang, H.-Y., Yang, P.-C., Liu, H.-J., Huang, Y.-S., Cheng, H., Hsu, Y.-C., Liu, S.-I., Pan, C.-H., Huang, Y.-F., Huang, C.-F., Wu, Y.-Y., Huang, Y.-H., Liu, H.-C., & Chang, H.-L. (2012). Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder. Psychiatry and Clinical Neurosciences, 66(1), 53-63. https://doi.org/10.1111/j.1440-1819.2011.02289.x

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title = "Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder",

abstract = "Aim: To determine the differences in the remission rate, recovery rate, functional improvement, and treatment adherence related to treatment with short-acting immediate-release methylphenidate (IR-MPH) and long-acting osmotic-release oral system-methylphenidate (OROS-MPH) in a naturalistic setting among Taiwanese children with attention-deficit-hyperactivity disorder (ADHD). Methods: A total of 757 children with ADHD, aged 6-18 years, was evaluated using the following in order determine functional improvement and treatment adherence: the Chinese version of the Swanson, Nolan, and Pelham, version IV scale (SNAP-IV-C), Clinical Global Impression-ADHD-Severity (CGI-S) to measure remission and recovery rates, the Chinese version of the Social Adjustment Inventory for Children and Adolescents (CSAICA), and caregiver's satisfaction rate, treatment adherence, and frequency of adverse effects. Results: According to the SNAP-IV-C scores, the remission rate was 30.72\%, and the recovery rate was 16.38\%. Compared to short-acting IR-MPH, OROS-MPH was associated with greater functional improvement and treatment adherence among children with ADHD. Conclusion: OROS-MPH treatment at the adequate dosage can achieve higher remission and recovery rates, produce greater functional improvement, and result in better treatment adherence than IR-MPH treatment. {\textcopyright} 2012 Japanese Society of Psychiatry and Neurology.",

keywords = "OROS-MPH, attention-deficit-hyperactivity disorder, functionality, recovery rate, remission rate",

author = "R.-F. Tzang and Y.-C. Wang and C.-B. Yeh and C.-D. Hsu and H.-Y. Liang and P.-C. Yang and H.-J. Liu and Yi-Shun Huang and H. Cheng and Y.-C. Hsu and S.-I. Liu and C.-H. Pan and Y.-F. Huang and C.-F. Huang and Y.-Y. Wu and Y.-H. Huang and H.-C. Liu and H.-L. Chang",

year = "2012",

doi = "10.1111/j.1440-1819.2011.02289.x",

language = "American English",

volume = "66",

pages = "53--63",

journal = "Psychiatry and Clinical Neurosciences",

issn = "1323-1316",

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}

Tzang, R-F, Wang, Y-C, Yeh, C-B, Hsu, C-D, Liang, H-Y, Yang, P-C, Liu, H-J, Huang, Y-S, Cheng, H, Hsu, Y-C, Liu, S-I, Pan, C-H, Huang, Y-F, Huang, C-F, Wu, Y-Y, Huang, Y-H, Liu, H-C & Chang, H-L 2012, 'Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder', Psychiatry and Clinical Neurosciences, vol. 66, no. 1, pp. 53-63. https://doi.org/10.1111/j.1440-1819.2011.02289.x

Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder. / Tzang, R.-F.; Wang, Y.-C.; Yeh, C.-B. et al.
In: Psychiatry and Clinical Neurosciences, Vol. 66, No. 1, 2012, p. 53-63.

Research output: Contribution to journal › Journal Article › peer-review

TY - JOUR

T1 - Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder

AU - Tzang, R.-F.

AU - Wang, Y.-C.

AU - Yeh, C.-B.

AU - Hsu, C.-D.

AU - Liang, H.-Y.

AU - Yang, P.-C.

AU - Liu, H.-J.

AU - Huang, Yi-Shun

AU - Cheng, H.

AU - Hsu, Y.-C.

AU - Liu, S.-I.

AU - Pan, C.-H.

AU - Huang, Y.-F.

AU - Huang, C.-F.

AU - Wu, Y.-Y.

AU - Huang, Y.-H.

AU - Liu, H.-C.

AU - Chang, H.-L.

PY - 2012

Y1 - 2012

N2 - Aim: To determine the differences in the remission rate, recovery rate, functional improvement, and treatment adherence related to treatment with short-acting immediate-release methylphenidate (IR-MPH) and long-acting osmotic-release oral system-methylphenidate (OROS-MPH) in a naturalistic setting among Taiwanese children with attention-deficit-hyperactivity disorder (ADHD). Methods: A total of 757 children with ADHD, aged 6-18 years, was evaluated using the following in order determine functional improvement and treatment adherence: the Chinese version of the Swanson, Nolan, and Pelham, version IV scale (SNAP-IV-C), Clinical Global Impression-ADHD-Severity (CGI-S) to measure remission and recovery rates, the Chinese version of the Social Adjustment Inventory for Children and Adolescents (CSAICA), and caregiver's satisfaction rate, treatment adherence, and frequency of adverse effects. Results: According to the SNAP-IV-C scores, the remission rate was 30.72%, and the recovery rate was 16.38%. Compared to short-acting IR-MPH, OROS-MPH was associated with greater functional improvement and treatment adherence among children with ADHD. Conclusion: OROS-MPH treatment at the adequate dosage can achieve higher remission and recovery rates, produce greater functional improvement, and result in better treatment adherence than IR-MPH treatment. © 2012 Japanese Society of Psychiatry and Neurology.

AB - Aim: To determine the differences in the remission rate, recovery rate, functional improvement, and treatment adherence related to treatment with short-acting immediate-release methylphenidate (IR-MPH) and long-acting osmotic-release oral system-methylphenidate (OROS-MPH) in a naturalistic setting among Taiwanese children with attention-deficit-hyperactivity disorder (ADHD). Methods: A total of 757 children with ADHD, aged 6-18 years, was evaluated using the following in order determine functional improvement and treatment adherence: the Chinese version of the Swanson, Nolan, and Pelham, version IV scale (SNAP-IV-C), Clinical Global Impression-ADHD-Severity (CGI-S) to measure remission and recovery rates, the Chinese version of the Social Adjustment Inventory for Children and Adolescents (CSAICA), and caregiver's satisfaction rate, treatment adherence, and frequency of adverse effects. Results: According to the SNAP-IV-C scores, the remission rate was 30.72%, and the recovery rate was 16.38%. Compared to short-acting IR-MPH, OROS-MPH was associated with greater functional improvement and treatment adherence among children with ADHD. Conclusion: OROS-MPH treatment at the adequate dosage can achieve higher remission and recovery rates, produce greater functional improvement, and result in better treatment adherence than IR-MPH treatment. © 2012 Japanese Society of Psychiatry and Neurology.

KW - OROS-MPH

KW - attention-deficit-hyperactivity disorder

KW - functionality

KW - recovery rate

KW - remission rate

U2 - 10.1111/j.1440-1819.2011.02289.x

DO - 10.1111/j.1440-1819.2011.02289.x

M3 - Journal Article

SN - 1323-1316

VL - 66

SP - 53

EP - 63

JO - Psychiatry and Clinical Neurosciences

JF - Psychiatry and Clinical Neurosciences

IS - 1

ER -

Naturalistic exploration of the effect of osmotic release oral system-methylphenidate on remission rate and functional improvement in Taiwanese children with attention-deficit-hyperactivity disorder

Abstract

Keywords

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