Neuroblastoma with expression of erythropoietin resulting in erythrocytosis

Lin Yen Wang; Lee Yung Shih; Shu Huey Chen; Hsi Che Liu; I. Jen Chai; Der Cherng Liang

doi:10.1097/00043426-200308000-00013

Neuroblastoma with expression of erythropoietin resulting in erythrocytosis

Lin Yen Wang, Lee Yung Shih, Shu Huey Chen, Hsi Che Liu, I. Jen Chai, Der Cherng Liang^*

^*Corresponding author for this work

School of Medicine

Mackay Memorial Hospital Taiwan

Research output: Contribution to journal › Journal Article › peer-review

4 Scopus citations

Abstract

We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis. A 2-year-old girl with neuroblastoma presented with hemoglobin 21.3 g/dL, red blood cells 8.03 x 10¹²/L, and hematocrit 0.641. The serum erythropoietin level was 26.54 mU/mL. The hemoglobin, hematocrit, and serum erythropoietin level were within normal ranges 3 months after surgical excision of the tumor. RT-PCR analysis showed that erythropoietin mRNA expression in the tumor tissue was as high as that of normal renal tissue. These results conclusively demonstrated that the tumor was the site of the ectopic erythropoietin production.

Original language	English
Pages (from-to)	649-650
Number of pages	2
Journal	Journal of Pediatric Hematology/Oncology
Volume	25
Issue number	8
DOIs	https://doi.org/10.1097/00043426-200308000-00013
State	Published - 08 2003

Keywords

Erythrocytosis
Erythropoietin
Neuroblastoma
RT-PCR

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10.1097/00043426-200308000-00013

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title = "Neuroblastoma with expression of erythropoietin resulting in erythrocytosis",

abstract = "We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis. A 2-year-old girl with neuroblastoma presented with hemoglobin 21.3 g/dL, red blood cells 8.03 x 1012/L, and hematocrit 0.641. The serum erythropoietin level was 26.54 mU/mL. The hemoglobin, hematocrit, and serum erythropoietin level were within normal ranges 3 months after surgical excision of the tumor. RT-PCR analysis showed that erythropoietin mRNA expression in the tumor tissue was as high as that of normal renal tissue. These results conclusively demonstrated that the tumor was the site of the ectopic erythropoietin production.",

keywords = "Erythrocytosis, Erythropoietin, Neuroblastoma, RT-PCR",

author = "Wang, {Lin Yen} and Shih, {Lee Yung} and Chen, {Shu Huey} and Liu, {Hsi Che} and Chai, {I. Jen} and Liang, {Der Cherng}",

year = "2003",

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doi = "10.1097/00043426-200308000-00013",

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TY - JOUR

T1 - Neuroblastoma with expression of erythropoietin resulting in erythrocytosis

AU - Wang, Lin Yen

AU - Shih, Lee Yung

AU - Chen, Shu Huey

AU - Liu, Hsi Che

AU - Chai, I. Jen

AU - Liang, Der Cherng

PY - 2003/8

Y1 - 2003/8

N2 - We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis. A 2-year-old girl with neuroblastoma presented with hemoglobin 21.3 g/dL, red blood cells 8.03 x 1012/L, and hematocrit 0.641. The serum erythropoietin level was 26.54 mU/mL. The hemoglobin, hematocrit, and serum erythropoietin level were within normal ranges 3 months after surgical excision of the tumor. RT-PCR analysis showed that erythropoietin mRNA expression in the tumor tissue was as high as that of normal renal tissue. These results conclusively demonstrated that the tumor was the site of the ectopic erythropoietin production.

AB - We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis. A 2-year-old girl with neuroblastoma presented with hemoglobin 21.3 g/dL, red blood cells 8.03 x 1012/L, and hematocrit 0.641. The serum erythropoietin level was 26.54 mU/mL. The hemoglobin, hematocrit, and serum erythropoietin level were within normal ranges 3 months after surgical excision of the tumor. RT-PCR analysis showed that erythropoietin mRNA expression in the tumor tissue was as high as that of normal renal tissue. These results conclusively demonstrated that the tumor was the site of the ectopic erythropoietin production.

KW - Erythrocytosis

KW - Erythropoietin

KW - Neuroblastoma

KW - RT-PCR

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U2 - 10.1097/00043426-200308000-00013

DO - 10.1097/00043426-200308000-00013

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AN - SCOPUS:0042570475

SN - 1077-4114

VL - 25

SP - 649

EP - 650

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

IS - 8

ER -

Neuroblastoma with expression of erythropoietin resulting in erythrocytosis

Abstract

Keywords

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