Neuroblastoma with expression of erythropoietin resulting in erythrocytosis

Lin Yen Wang, Lee Yung Shih, Shu Huey Chen, Hsi Che Liu, I. Jen Chai, Der Cherng Liang*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

4 Scopus citations


We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis. A 2-year-old girl with neuroblastoma presented with hemoglobin 21.3 g/dL, red blood cells 8.03 x 1012/L, and hematocrit 0.641. The serum erythropoietin level was 26.54 mU/mL. The hemoglobin, hematocrit, and serum erythropoietin level were within normal ranges 3 months after surgical excision of the tumor. RT-PCR analysis showed that erythropoietin mRNA expression in the tumor tissue was as high as that of normal renal tissue. These results conclusively demonstrated that the tumor was the site of the ectopic erythropoietin production.

Original languageEnglish
Pages (from-to)649-650
Number of pages2
JournalJournal of Pediatric Hematology/Oncology
Issue number8
StatePublished - 08 2003


  • Erythrocytosis
  • Erythropoietin
  • Neuroblastoma
  • RT-PCR


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