TY - JOUR
T1 - Neurochemical changes in the rat brain after intraventricular administration of tryptamine-4,5-dione
AU - Chen, J. C.
AU - Schnepper, Pamela W.
AU - To, A.
AU - Volicer, L.
PY - 1992/3
Y1 - 1992/3
N2 - Tryptamine-4,5-dione (4,5-DKT) a neurotoxic derivative of serotonin (5-HT), was injected into the lateral ventricle of the rat in order to evaluate its biochemical effects. The levels of 8 substances in the hippocampus, striatum and prefrontal cortex were examined 3, 7 and 14 days after treatment with 4,5-DKT. 5-Hydroxytryptamine and 5-hydroxyindoleacetic acid (5-HIAA) levels were decreased in all three regions by days 7 and 14, respectively. Tryptamine-4,5-dione had no significant effect on dopaminergic or adrenergic systems or on the levels of l-tryptophan and l-tyrosine, in any of the three areas of brain examined. Reduced activity of tryptophan hydroxylase in the cortex was observed 14 days after administration of 4,5-DKT. However, administration of 4,5-DKT did not alter the binding of [3H]paroxetine, a specific antagonist of the uptake of 5-HT, to nerve terminals. These results indicate that 4,5-DKT produced depletion of 5-HT without eliminating serotoninergic nerve terminals.
AB - Tryptamine-4,5-dione (4,5-DKT) a neurotoxic derivative of serotonin (5-HT), was injected into the lateral ventricle of the rat in order to evaluate its biochemical effects. The levels of 8 substances in the hippocampus, striatum and prefrontal cortex were examined 3, 7 and 14 days after treatment with 4,5-DKT. 5-Hydroxytryptamine and 5-hydroxyindoleacetic acid (5-HIAA) levels were decreased in all three regions by days 7 and 14, respectively. Tryptamine-4,5-dione had no significant effect on dopaminergic or adrenergic systems or on the levels of l-tryptophan and l-tyrosine, in any of the three areas of brain examined. Reduced activity of tryptophan hydroxylase in the cortex was observed 14 days after administration of 4,5-DKT. However, administration of 4,5-DKT did not alter the binding of [3H]paroxetine, a specific antagonist of the uptake of 5-HT, to nerve terminals. These results indicate that 4,5-DKT produced depletion of 5-HT without eliminating serotoninergic nerve terminals.
KW - 5-dione
KW - 5-hydroxyin-doleacetic acid
KW - catecholamines
KW - serotonin
KW - tryptamine-4
KW - tryptophan hydroxylase
UR - http://www.scopus.com/inward/record.url?scp=0026611138&partnerID=8YFLogxK
U2 - 10.1016/0028-3908(92)90170-T
DO - 10.1016/0028-3908(92)90170-T
M3 - 文章
C2 - 1378572
AN - SCOPUS:0026611138
SN - 0028-3908
VL - 31
SP - 215
EP - 219
JO - Neuropharmacology
JF - Neuropharmacology
IS - 3
ER -