Neuromodulatory Focused Ultrasound for Epilepsy: Are Animal Models Useful?

Po Chun Chu, Hsiang Yu Yu, Robert S. Fisher, Hao Li Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

1 Scopus citations

Abstract

Ultrasound neuromodulation is a potential alternative therapy for suppressing epileptic discharges. Recently, several human clinical trials have reported promising results from repeated focused ultrasound (FUS) treatments for temporal lobe epilepsy. In this Viewpoint, we highlight the valuable guidance of preclinical validation methods for choosing the optimal FUS parameters, thus ensuring consistency with the outcomes of clinical trials and leading human trials to the safest and most effective approaches.

Original languageEnglish
Pages (from-to)1728-1731
Number of pages4
JournalACS Chemical Neuroscience
Volume15
Issue number9
DOIs
StatePublished - 01 05 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.

Keywords

  • clinical trial
  • epilepsy
  • Focused ultrasound
  • kainic acid model
  • neuromodulation
  • translation
  • Ultrasonic Therapy/methods
  • Animals
  • Humans
  • Epilepsy/therapy
  • Epilepsy, Temporal Lobe/therapy
  • Disease Models, Animal

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