Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening: Feasibility when considering the human skull

Meng Yen Tsai, Po Chun Chu, Hong Li Wang, Hao Li Liu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Focused ultrasound (FUS) exposure with the presence of microbubbles has shown its promise in temporally and targeted open the blood-brain barrier (BBB), and brings potential in delivering therapeutic agents into the brain for CNS disease treatment. Feasibility in using neuronavigation system to guide the FUS-BBB procedure in large animals has been demonstrated successfully, and the guidance precision has been measured to be acceptably low. However, it is still unknown whether same precision and power compensation strategy is valid when FUS beam is intend to penetrate the human skull. The purpose of this study is to verify that using neuronavigation system combined with a prior treatment plan can successfully guide FUS-BBB opening with the consideration of involvement of human skull. A human cadaver was employed to perform CT scan, and a treatment planning software was developed to simulate focal beam redistribution and pressure decay when transcranial FUS exposure were performed. During experiment, 4 groups were conducted to verify the success of BBB-opening when incorporating with the in-prior treatment plan. Our results suggest that under the guidance of neuronavigation and prior treatment planning is feasible to precisely guide the FUS-BBB opening procedure, and may have potential to be applied for future clinical brain drug delivery interventions.

Original languageEnglish
Title of host publication2015 IEEE International Ultrasonics Symposium, IUS 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479981823
DOIs
StatePublished - 13 11 2015
EventIEEE International Ultrasonics Symposium, IUS 2015 - Taipei, Taiwan
Duration: 21 10 201524 10 2015

Publication series

Name2015 IEEE International Ultrasonics Symposium, IUS 2015

Conference

ConferenceIEEE International Ultrasonics Symposium, IUS 2015
Country/TerritoryTaiwan
CityTaipei
Period21/10/1524/10/15

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

Keywords

  • Focused ultrasound
  • blood-brain barrier
  • neuronavigation
  • treatment planning

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