Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex

Jin Chung Chen; Jihn Yih Li; Kai Wen Liang; Yi Kung Huang

doi:10.1016/S0006-8993(98)01108-1

Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex

Jin Chung Chen
, Jihn Yih Li
, Kai Wen Liang
, Yi Kung Huang^*

^*Corresponding author for this work

Graduate Institute of Biomedical Sciences

Chang Gung University
Chang Gung Memorial Hospital

Research output: Contribution to journal › Journal Article › peer-review

18 Scopus citations

Abstract

We have demonstrated that chronic administration of neuropeptide FF (NPFF) into the lateral ventricle potentiated the behavioral sensitization to amphetamine. Further, the treatment with NPFF decreased the levels of serotonin, and increased the glutamate and GABA content in the medial prefrontal cortex of amphetamine-sensitized rats. The results suggest that NPFF may modulate the neuronal process of amphetamine addiction.

Original language	English
Pages (from-to)	220-224
Number of pages	5
Journal	Brain Research
Volume	816
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)01108-1
State	Published - 16 01 1999

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Amphetamine
Drug addiction
Glutamate
Medial prefrontal cortex
Neuropeptide FF
Serotonin

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10.1016/S0006-8993(98)01108-1

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title = "Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex",

abstract = "We have demonstrated that chronic administration of neuropeptide FF (NPFF) into the lateral ventricle potentiated the behavioral sensitization to amphetamine. Further, the treatment with NPFF decreased the levels of serotonin, and increased the glutamate and GABA content in the medial prefrontal cortex of amphetamine-sensitized rats. The results suggest that NPFF may modulate the neuronal process of amphetamine addiction.",

keywords = "Amphetamine, Drug addiction, Glutamate, Medial prefrontal cortex, Neuropeptide FF, Serotonin",

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AU - Chen, Jin Chung

AU - Li, Jihn Yih

AU - Liang, Kai Wen

AU - Huang, Yi Kung

PY - 1999/1/16

Y1 - 1999/1/16

N2 - We have demonstrated that chronic administration of neuropeptide FF (NPFF) into the lateral ventricle potentiated the behavioral sensitization to amphetamine. Further, the treatment with NPFF decreased the levels of serotonin, and increased the glutamate and GABA content in the medial prefrontal cortex of amphetamine-sensitized rats. The results suggest that NPFF may modulate the neuronal process of amphetamine addiction.

AB - We have demonstrated that chronic administration of neuropeptide FF (NPFF) into the lateral ventricle potentiated the behavioral sensitization to amphetamine. Further, the treatment with NPFF decreased the levels of serotonin, and increased the glutamate and GABA content in the medial prefrontal cortex of amphetamine-sensitized rats. The results suggest that NPFF may modulate the neuronal process of amphetamine addiction.

KW - Amphetamine

KW - Drug addiction

KW - Glutamate

KW - Medial prefrontal cortex

KW - Neuropeptide FF

KW - Serotonin

UR - https://www.scopus.com/pages/publications/0033573684

U2 - 10.1016/S0006-8993(98)01108-1

DO - 10.1016/S0006-8993(98)01108-1

M3 - 文章

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JO - Brain Research

JF - Brain Research

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ER -

Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex

Abstract

UN SDGs

Keywords

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