Neuroplastic changes in resting-state functional connectivity after stroke rehabilitation

Yang Teng Fan, Ching Yi Wu, Ho Ling Liu, Keh Chung Lin*, Yau Yau Wai, Yao Liang Chen

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

58 Scopus citations


Most neuroimaging research in stroke rehabilitation mainly focuses on the neural mechanisms underlying the natural history of post-stroke recovery. However, connectivity mapping from resting-state fMRI is well suited for different neurological conditions and provides a promising method to explore plastic changes for treatment-induced recovery from stroke. We examined the changes in resting-state functional connectivity (RS-FC) of the ipsilesional primary motor cortex (M1) in 10 post-acute stroke patients before and immediately after 4 weeks of robot-assisted bilateral arm therapy (RBAT). Motor performance, functional use of the affected arm, and daily function improved in all participants. Reduced interhemispheric RS-FC between the ipsilesional and contralesional M1 (M1-M1) and the contralesional-lateralized connections were noted before treatment. In contrast, greater M1-M1 functional connectivity and disturbed resting-state networks were observed after RBAT relative to pre-treatment. Increased changes in M1-M1 RS-FC after RBAT were coupled with better motor and functional improvements. Mediation analysis showed the pre-to-post difference in M1-M1 RS-FC was a significant mediator for the relationship between motor and functional recovery. These results show neuroplastic changes and functional recoveries induced by RBAT in post-acute stroke survivors and suggest that interhemispheric functional connectivity in the motor cortex may be a neurobiological marker for recovery after stroke rehabilitation.

Original languageEnglish
Article number546
JournalFrontiers in Human Neuroscience
Issue numberOCT
StatePublished - 06 10 2015

Bibliographical note

Publisher Copyright:
© 2015 Fan, Wu, Liu, Lin, Wai and Chen.


  • Functional connectivity
  • Motor cortex
  • Rehabilitation
  • Robot
  • Stroke
  • fMRI


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