Neuropsychiatric symptoms in Parkinson's disease: Association with caregiver distress and disease severity

Wan Chen Tsai; Hui Chen Lin; Chiung Chih Chang; Wen Neng Chang; Chih Cheng Huang; Kuei Yueh Cheng; Hung Chen Wang; Wei Che Lin; Sheng Yuan Hsiao; Yun Ru Lai; Cheng Hsien Lu; Nai Wen Tsai

doi:10.1017/S1041610219001510

Neuropsychiatric symptoms in Parkinson's disease: Association with caregiver distress and disease severity

Wan Chen Tsai, Hui Chen Lin, Chiung Chih Chang, Wen Neng Chang, Chih Cheng Huang, Kuei Yueh Cheng, Hung Chen Wang, Wei Che Lin, Sheng Yuan Hsiao, Yun Ru Lai, Cheng Hsien Lu, Nai Wen Tsai^*

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Journal Article › peer-review

7 Scopus citations

Abstract

Objectives: The condition of caregivers is important to the quality of care received by people with Parkinson's disease (PD), especially at the late disease stages. This study addresses the distress placed on caregivers by participants' neuropsychiatric symptoms at different stages of PD in TaiwanMethods: This prospective study enrolled 108 people with PD. All participants were examined with the Unified Parkinson's Disease Rating Scale (UPDRS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), and Clinical Dementia Rating (CDR) scale. Caregiver distress was measured using the Neuropsychiatric Inventory Caregiver Distress Scale (NPI-D). Statistical analysis was used to explore the PD-related factors that contribute to caregiver distress.Results: The mean follow-up interval in the 108 PD participants were 24.0 ± 10.2 months with no participant lost to follow-up due to death. NPI-distress (the sum of NPI caregiver distress scale across the 12 domains of the NPI) was positively correlated with NPI-sum (the total score across the 12 domains of the NPI) (r = 0.787, p < 0.001), CDR (r = 0.403, p < 0.001), UPRDS (r = 0.276, p = 0.004), and disease duration (r = 0.246, p = 0.002), but negatively correlated with CASI (r = -0.237, p = 0.043) and MMSE (r = -0.281, p < 0.001). Multiple linear regression analysis showed that only NPI-sum and disease duration were independently correlated with NPI-distress.Conclusion: The disease duration and NPI-sum are independent predictors of caregiver distress in Taiwanese populations with PD. Early detection and reduction of neuropsychiatric symptoms in people with PD can help decrease caregiver distress.

Original language	English
Pages (from-to)	733-739
Number of pages	7
Journal	International Psychogeriatrics
Volume	32
Issue number	6
DOIs	https://doi.org/10.1017/S1041610219001510
State	Published - 01 06 2020

Bibliographical note

Publisher Copyright:
© International Psychogeriatric Association 2019.

Keywords

Parkinson's disease
dementia
distress
neuropsychiatric inventory

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{395fcd166eb84bf49bbd9322b9b8b893,

title = "Neuropsychiatric symptoms in Parkinson's disease: Association with caregiver distress and disease severity",

abstract = "Objectives: The condition of caregivers is important to the quality of care received by people with Parkinson's disease (PD), especially at the late disease stages. This study addresses the distress placed on caregivers by participants' neuropsychiatric symptoms at different stages of PD in TaiwanMethods: This prospective study enrolled 108 people with PD. All participants were examined with the Unified Parkinson's Disease Rating Scale (UPDRS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), and Clinical Dementia Rating (CDR) scale. Caregiver distress was measured using the Neuropsychiatric Inventory Caregiver Distress Scale (NPI-D). Statistical analysis was used to explore the PD-related factors that contribute to caregiver distress.Results: The mean follow-up interval in the 108 PD participants were 24.0 ± 10.2 months with no participant lost to follow-up due to death. NPI-distress (the sum of NPI caregiver distress scale across the 12 domains of the NPI) was positively correlated with NPI-sum (the total score across the 12 domains of the NPI) (r = 0.787, p < 0.001), CDR (r = 0.403, p < 0.001), UPRDS (r = 0.276, p = 0.004), and disease duration (r = 0.246, p = 0.002), but negatively correlated with CASI (r = -0.237, p = 0.043) and MMSE (r = -0.281, p < 0.001). Multiple linear regression analysis showed that only NPI-sum and disease duration were independently correlated with NPI-distress.Conclusion: The disease duration and NPI-sum are independent predictors of caregiver distress in Taiwanese populations with PD. Early detection and reduction of neuropsychiatric symptoms in people with PD can help decrease caregiver distress.",

keywords = "Parkinson's disease, dementia, distress, neuropsychiatric inventory",

author = "Tsai, {Wan Chen} and Lin, {Hui Chen} and Chang, {Chiung Chih} and Chang, {Wen Neng} and Huang, {Chih Cheng} and Cheng, {Kuei Yueh} and Wang, {Hung Chen} and Lin, {Wei Che} and Hsiao, {Sheng Yuan} and Lai, {Yun Ru} and Lu, {Cheng Hsien} and Tsai, {Nai Wen}",

note = "Publisher Copyright: {\textcopyright} International Psychogeriatric Association 2019.",

year = "2020",

month = jun,

day = "1",

doi = "10.1017/S1041610219001510",

language = "英语",

volume = "32",

pages = "733--739",

journal = "International Psychogeriatrics",

issn = "1041-6102",

publisher = "Cambridge University Press",

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T1 - Neuropsychiatric symptoms in Parkinson's disease

T2 - Association with caregiver distress and disease severity

AU - Tsai, Wan Chen

AU - Lin, Hui Chen

AU - Chang, Chiung Chih

AU - Chang, Wen Neng

AU - Huang, Chih Cheng

AU - Cheng, Kuei Yueh

AU - Wang, Hung Chen

AU - Lin, Wei Che

AU - Hsiao, Sheng Yuan

AU - Lai, Yun Ru

AU - Lu, Cheng Hsien

AU - Tsai, Nai Wen

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Objectives: The condition of caregivers is important to the quality of care received by people with Parkinson's disease (PD), especially at the late disease stages. This study addresses the distress placed on caregivers by participants' neuropsychiatric symptoms at different stages of PD in TaiwanMethods: This prospective study enrolled 108 people with PD. All participants were examined with the Unified Parkinson's Disease Rating Scale (UPDRS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), and Clinical Dementia Rating (CDR) scale. Caregiver distress was measured using the Neuropsychiatric Inventory Caregiver Distress Scale (NPI-D). Statistical analysis was used to explore the PD-related factors that contribute to caregiver distress.Results: The mean follow-up interval in the 108 PD participants were 24.0 ± 10.2 months with no participant lost to follow-up due to death. NPI-distress (the sum of NPI caregiver distress scale across the 12 domains of the NPI) was positively correlated with NPI-sum (the total score across the 12 domains of the NPI) (r = 0.787, p < 0.001), CDR (r = 0.403, p < 0.001), UPRDS (r = 0.276, p = 0.004), and disease duration (r = 0.246, p = 0.002), but negatively correlated with CASI (r = -0.237, p = 0.043) and MMSE (r = -0.281, p < 0.001). Multiple linear regression analysis showed that only NPI-sum and disease duration were independently correlated with NPI-distress.Conclusion: The disease duration and NPI-sum are independent predictors of caregiver distress in Taiwanese populations with PD. Early detection and reduction of neuropsychiatric symptoms in people with PD can help decrease caregiver distress.

AB - Objectives: The condition of caregivers is important to the quality of care received by people with Parkinson's disease (PD), especially at the late disease stages. This study addresses the distress placed on caregivers by participants' neuropsychiatric symptoms at different stages of PD in TaiwanMethods: This prospective study enrolled 108 people with PD. All participants were examined with the Unified Parkinson's Disease Rating Scale (UPDRS), Neuropsychiatric Inventory (NPI), Mini-Mental State Examination (MMSE), Cognitive Abilities Screening Instrument (CASI), and Clinical Dementia Rating (CDR) scale. Caregiver distress was measured using the Neuropsychiatric Inventory Caregiver Distress Scale (NPI-D). Statistical analysis was used to explore the PD-related factors that contribute to caregiver distress.Results: The mean follow-up interval in the 108 PD participants were 24.0 ± 10.2 months with no participant lost to follow-up due to death. NPI-distress (the sum of NPI caregiver distress scale across the 12 domains of the NPI) was positively correlated with NPI-sum (the total score across the 12 domains of the NPI) (r = 0.787, p < 0.001), CDR (r = 0.403, p < 0.001), UPRDS (r = 0.276, p = 0.004), and disease duration (r = 0.246, p = 0.002), but negatively correlated with CASI (r = -0.237, p = 0.043) and MMSE (r = -0.281, p < 0.001). Multiple linear regression analysis showed that only NPI-sum and disease duration were independently correlated with NPI-distress.Conclusion: The disease duration and NPI-sum are independent predictors of caregiver distress in Taiwanese populations with PD. Early detection and reduction of neuropsychiatric symptoms in people with PD can help decrease caregiver distress.

KW - Parkinson's disease

KW - dementia

KW - distress

KW - neuropsychiatric inventory

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U2 - 10.1017/S1041610219001510

DO - 10.1017/S1041610219001510

M3 - 文章

C2 - 31647049

AN - SCOPUS:85074512120

SN - 1041-6102

VL - 32

SP - 733

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JO - International Psychogeriatrics

JF - International Psychogeriatrics

IS - 6

ER -

Neuropsychiatric symptoms in Parkinson's disease: Association with caregiver distress and disease severity

Abstract

Bibliographical note

Keywords

UN SDGs

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