Neurovascular coupling in eye-open-eye-close task and resting state: Spectral correspondence between concurrent EEG and fMRI

Yi Chia Kung, Chia Wei Li, Ai Ling Hsu*, Chi Yun Liu, Changwei W. Wu*, Wei Chou Chang, Ching Po Lin*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

Abstract

Neurovascular coupling serves as an essential neurophysiological mechanism in functional neuroimaging, which is generally presumed to be robust and invariant across different physiological states, encompassing both task engagement and resting state. Nevertheless, emerging evidence suggests that neurovascular coupling may exhibit state dependency, even in normal human participants. To investigate this premise, we analyzed the cross-frequency spectral correspondence between concurrently recorded electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data, utilizing them as proxies for neurovascular coupling during the two conditions: an eye-open-eye-close (EOEC) task and a resting state. We hypothesized that given the state dependency of neurovascular coupling, EEG-fMRI spectral correspondences would change between the two conditions in the visual system. During the EOEC task, we observed a negative phase-amplitude-coupling (PAC) between EEG alpha-band and fMRI visual activity. Conversely, in the resting state, a pronounced amplitude-amplitude-coupling (AAC) emerged between EEG and fMRI signals, as evidenced by the spectral correspondence between the EEG gamma-band of the midline occipital channel (Oz) and the high-frequency fMRI signals (0.15–0.25 Hz) in the visual network. This study reveals distinct scenarios of EEG-fMRI spectral correspondence in healthy participants, corroborating the state-dependent nature of neurovascular coupling.

Original languageEnglish
Article number120535
Pages (from-to)120535
JournalNeuroImage
Volume289
DOIs
StatePublished - 01 04 2024

Bibliographical note

Copyright © 2024. Published by Elsevier Inc.

Keywords

  • Amplitude-amplitude-coupling (AAC)
  • Electroencephalography (EEG)
  • Functional magnetic resonance imaging (FMRI)
  • Hilbert-Huang transform (HHT)
  • Neurovascular coupling
  • Phase-amplitude-coupling (PAC)
  • Resting state
  • Brain Mapping/methods
  • Electroencephalography/methods
  • Humans
  • Magnetic Resonance Imaging/methods
  • Neurovascular Coupling/physiology
  • Eye
  • Brain/diagnostic imaging

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