New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

Chia Cheng Lin; Jui Hsin Su; Wu Fu Chen; Zhi Hong Wen; Bo Rong Peng; Lin Cyuan Huang; Tsong Long Hwang; Ping Jyun Sung

doi:10.3390/molecules24132487

New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

Chia Cheng Lin
, Jui Hsin Su
, Wu Fu Chen
, Zhi Hong Wen
, Bo Rong Peng
, Lin Cyuan Huang
, Tsong Long Hwang^*
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Chang Gung University
National Museum of Marine Biology and Aquarium, Taiwan
National Dong Hwa University
National Sun Yat-sen University
Chang Gung University of Science and Technology
Chang Gung Memorial Hospital
Kaohsiung Medical University
China Medical University Taichung

Research output: Contribution to journal › Journal Article › peer-review

12 Scopus citations

Abstract

Two new 11,20-epoxybriaranes, fragilides P (1) and Q (2), as well as two known analogues, robustolide F (3) and juncin Z (4), were obtained from the gorgonian coral Junceella fragilis. The structures, including the absolute configurations of briaranes 1 and 2, were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane 4 decreased the generation of superoxide anions by human neutrophils. The propionate group in 1 is rarely found.

Original language	English
Article number	2487
Journal	Molecules
Volume	24
Issue number	13
DOIs	https://doi.org/10.3390/molecules24132487
State	Published - 2019

Bibliographical note

Publisher Copyright:
© 2019 by the authors

Keywords

Briarane
Fragilide
Junceella fragilis
Superoxide anion

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10.3390/molecules24132487

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title = "New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)",

abstract = "Two new 11,20-epoxybriaranes, fragilides P (1) and Q (2), as well as two known analogues, robustolide F (3) and juncin Z (4), were obtained from the gorgonian coral Junceella fragilis. The structures, including the absolute configurations of briaranes 1 and 2, were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane 4 decreased the generation of superoxide anions by human neutrophils. The propionate group in 1 is rarely found.",

keywords = "Briarane, Fragilide, Junceella fragilis, Superoxide anion",

author = "Lin, \{Chia Cheng\} and Su, \{Jui Hsin\} and Chen, \{Wu Fu\} and Wen, \{Zhi Hong\} and Peng, \{Bo Rong\} and Huang, \{Lin Cyuan\} and Hwang, \{Tsong Long\} and Sung, \{Ping Jyun\}",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors",

year = "2019",

doi = "10.3390/molecules24132487",

language = "英语",

volume = "24",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

AU - Lin, Chia Cheng

AU - Su, Jui Hsin

AU - Chen, Wu Fu

AU - Wen, Zhi Hong

AU - Peng, Bo Rong

AU - Huang, Lin Cyuan

AU - Hwang, Tsong Long

AU - Sung, Ping Jyun

PY - 2019

Y1 - 2019

N2 - Two new 11,20-epoxybriaranes, fragilides P (1) and Q (2), as well as two known analogues, robustolide F (3) and juncin Z (4), were obtained from the gorgonian coral Junceella fragilis. The structures, including the absolute configurations of briaranes 1 and 2, were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane 4 decreased the generation of superoxide anions by human neutrophils. The propionate group in 1 is rarely found.

AB - Two new 11,20-epoxybriaranes, fragilides P (1) and Q (2), as well as two known analogues, robustolide F (3) and juncin Z (4), were obtained from the gorgonian coral Junceella fragilis. The structures, including the absolute configurations of briaranes 1 and 2, were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane 4 decreased the generation of superoxide anions by human neutrophils. The propionate group in 1 is rarely found.

KW - Briarane

KW - Fragilide

KW - Junceella fragilis

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/85068667635

U2 - 10.3390/molecules24132487

DO - 10.3390/molecules24132487

M3 - 文章

C2 - 31284657

AN - SCOPUS:85068667635

SN - 1420-3049

VL - 24

JO - Molecules

JF - Molecules

IS - 13

M1 - 2487

ER -

New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae)

Abstract

Bibliographical note

Keywords

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