New 6-hydroxyeunicellins from a soft coral Cladiella sp.

Yung Husan Chen; Tsong Long Hwang; Yin Di Su; Yu Chia Chang; Yu Hsin Chen; Pei Han Hong; Li Chung Hu; Wei Hsuan Yen; Hsin Yin Hsu; Shu Jung Huang; Yueh Hsiung Kuo; Ping Jyun Sung

doi:10.1248/cpb.60.160

New 6-hydroxyeunicellins from a soft coral Cladiella sp.

Yung Husan Chen
, Tsong Long Hwang
, Yin Di Su
, Yu Chia Chang
, Yu Hsin Chen
, Pei Han Hong
, Li Chung Hu
, Wei Hsuan Yen
, Hsin Yin Hsu
, Shu Jung Huang
, Yueh Hsiung Kuo^*
, Ping Jyun Sung

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

19 Scopus citations

Abstract

Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

Original language	English
Pages (from-to)	160-163
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	60
Issue number	1
DOIs	https://doi.org/10.1248/cpb.60.160
State	Published - 01 2012

Keywords

Cladiella
Cladieunicellin
Elastase
Eunicellin
Octocoral
Superoxide anion

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10.1248/cpb.60.160

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abstract = "Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.",

keywords = "Cladiella, Cladieunicellin, Elastase, Eunicellin, Octocoral, Superoxide anion",

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doi = "10.1248/cpb.60.160",

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AU - Chen, Yung Husan

AU - Hwang, Tsong Long

AU - Su, Yin Di

AU - Chang, Yu Chia

AU - Chen, Yu Hsin

AU - Hong, Pei Han

AU - Hu, Li Chung

AU - Yen, Wei Hsuan

AU - Hsu, Hsin Yin

AU - Huang, Shu Jung

AU - Kuo, Yueh Hsiung

AU - Sung, Ping Jyun

PY - 2012/1

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N2 - Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

AB - Two new 6-hydroxyeunicellin diterpenoids, cladieunicellin G (1) and 6-epi-cladieunicellin F (2), were isolated from an Indonesian octocoral Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods and 2 was found to be an epimer of the known eunicellin cladieunicellin F (3). Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

KW - Cladiella

KW - Cladieunicellin

KW - Elastase

KW - Eunicellin

KW - Octocoral

KW - Superoxide anion

UR - https://www.scopus.com/pages/publications/84862908241

U2 - 10.1248/cpb.60.160

DO - 10.1248/cpb.60.160

M3 - 文章

C2 - 22223389

AN - SCOPUS:84862908241

SN - 0009-2363

VL - 60

SP - 160

EP - 163

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 1

ER -

New 6-hydroxyeunicellins from a soft coral Cladiella sp.

Abstract

Keywords

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