New anti-inflammatory sterols from a gorgonian Pinnigorgia sp

Y.-D. Su; Chih-Hsiu Cheng; Z.-H. Wen; Y.-C. Wu; P.-J. Sung

doi:10.1016/j.bmcl.2016.05.015

New anti-inflammatory sterols from a gorgonian Pinnigorgia sp

Y.-D. Su, Chih-Hsiu Cheng, Z.-H. Wen, Y.-C. Wu, P.-J. Sung

School of Physical Therapy

Research output: Contribution to journal › Journal Article › peer-review

14 Scopus citations

Abstract

Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian Pinnigorgia sp. afforded two new sterols, 11-acetoxy-24. S-methyl-3. β,5. α,6. α-trihydroxy-9,11-secocholest-7-en-9-one (1) and 5. β,6. β-epoxy-(22. E,24. R)-ergosta-8,22-diene-3. β,7. β-diol (2). The structures of sterols 1 and 2 were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.

Original language	American English
Pages (from-to)	3060-3063
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2016.05.015
State	Published - 2016

Keywords

Anti-inflammatory activity
Anti-inflammatory activity
COX-2
COX-2
Gorgonian
Gorgonian
INOS
INOS
Pinnigorgia
Pinnigorgia
Sterol
Sterol

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10.1016/j.bmcl.2016.05.015

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title = "New anti-inflammatory sterols from a gorgonian Pinnigorgia sp",

abstract = "Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian Pinnigorgia sp. afforded two new sterols, 11-acetoxy-24. S-methyl-3. β,5. α,6. α-trihydroxy-9,11-secocholest-7-en-9-one (1) and 5. β,6. β-epoxy-(22. E,24. R)-ergosta-8,22-diene-3. β,7. β-diol (2). The structures of sterols 1 and 2 were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.",

keywords = "Anti-inflammatory activity, Anti-inflammatory activity, COX-2, COX-2, Gorgonian, Gorgonian, INOS, INOS, Pinnigorgia, Pinnigorgia, Sterol, Sterol",

author = "Y.-D. Su and Chih-Hsiu Cheng and Z.-H. Wen and Y.-C. Wu and P.-J. Sung",

year = "2016",

doi = "10.1016/j.bmcl.2016.05.015",

language = "American English",

volume = "26",

pages = "3060--3063",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "13",

}

TY - JOUR

T1 - New anti-inflammatory sterols from a gorgonian Pinnigorgia sp

AU - Su, Y.-D.

AU - Cheng, Chih-Hsiu

AU - Wen, Z.-H.

AU - Wu, Y.-C.

AU - Sung, P.-J.

PY - 2016

Y1 - 2016

N2 - Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian Pinnigorgia sp. afforded two new sterols, 11-acetoxy-24. S-methyl-3. β,5. α,6. α-trihydroxy-9,11-secocholest-7-en-9-one (1) and 5. β,6. β-epoxy-(22. E,24. R)-ergosta-8,22-diene-3. β,7. β-diol (2). The structures of sterols 1 and 2 were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.

AB - Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian Pinnigorgia sp. afforded two new sterols, 11-acetoxy-24. S-methyl-3. β,5. α,6. α-trihydroxy-9,11-secocholest-7-en-9-one (1) and 5. β,6. β-epoxy-(22. E,24. R)-ergosta-8,22-diene-3. β,7. β-diol (2). The structures of sterols 1 and 2 were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.

KW - Anti-inflammatory activity

KW - COX-2

KW - Gorgonian

KW - INOS

KW - Pinnigorgia

KW - Sterol

U2 - 10.1016/j.bmcl.2016.05.015

DO - 10.1016/j.bmcl.2016.05.015

M3 - Journal Article

C2 - 27217003

SN - 0960-894X

VL - 26

SP - 3060

EP - 3063

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 13

ER -

New anti-inflammatory sterols from a gorgonian Pinnigorgia sp

Abstract

Keywords

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