New anti-inflammatory sterols from a gorgonian Pinnigorgia sp

Y.-D. Su, Chih-Hsiu Cheng, Z.-H. Wen, Y.-C. Wu, P.-J. Sung

Research output: Contribution to journalJournal Article peer-review

13 Scopus citations

Abstract

Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian Pinnigorgia sp. afforded two new sterols, 11-acetoxy-24. S-methyl-3. β,5. α,6. α-trihydroxy-9,11-secocholest-7-en-9-one (1) and 5. β,6. β-epoxy-(22. E,24. R)-ergosta-8,22-diene-3. β,7. β-diol (2). The structures of sterols 1 and 2 were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both 1 and 2 were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Original languageAmerican English
Pages (from-to)3060-3063
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number13
DOIs
StatePublished - 2016

Keywords

  • Anti-inflammatory activity
  • Anti-inflammatory activity
  • COX-2
  • COX-2
  • Gorgonian
  • Gorgonian
  • INOS
  • INOS
  • Pinnigorgia
  • Pinnigorgia
  • Sterol
  • Sterol

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