New anti-inflammatory tocopherol-derived metabolites from the Taiwanese soft coral Cladiella hirsuta

Bo Wei Chen, Chokkalingam Uvarani, Chiung Yao Huang, Tsong Long Hwang, Chang Feng Dai, Jyh Horng Sheu*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

10 Scopus citations

Abstract

Two new tocopherol-derived metabolites, hirsutocospiro A (1) and hirsutocoquinone A (2), were isolated from the soft coral Cladiella hirsuta. The structures of 1 and 2 were determined by extensive spectroscopic analysis. The in vitro anti-inflammatory activity of compounds 1 and 2 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. Compound 1 was shown to exhibit significant anti-inflammatory activity.

Original languageEnglish
Pages (from-to)92-95
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number1
DOIs
StatePublished - 01 01 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Ltd. All rights reserved.

Keywords

  • Anti-inflammatory activity
  • Cladiella hirsute
  • Hirsutaquinone

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