Abstract
Two new tocopherol-derived metabolites, hirsutocospiro A (1) and hirsutocoquinone A (2), were isolated from the soft coral Cladiella hirsuta. The structures of 1 and 2 were determined by extensive spectroscopic analysis. The in vitro anti-inflammatory activity of compounds 1 and 2 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. Compound 1 was shown to exhibit significant anti-inflammatory activity.
Original language | English |
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Pages (from-to) | 92-95 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 25 |
Issue number | 1 |
DOIs | |
State | Published - 01 01 2015 |
Bibliographical note
Publisher Copyright:© 2014 Elsevier Ltd. All rights reserved.
Keywords
- Anti-inflammatory activity
- Cladiella hirsute
- Hirsutaquinone