New anti-inflammatory tocopherol-derived metabolites from the Taiwanese soft coral Cladiella hirsuta

Bo Wei Chen; Chokkalingam Uvarani; Chiung Yao Huang; Tsong Long Hwang; Chang Feng Dai; Jyh Horng Sheu

doi:10.1016/j.bmcl.2014.11.002

New anti-inflammatory tocopherol-derived metabolites from the Taiwanese soft coral Cladiella hirsuta

Bo Wei Chen
, Chokkalingam Uvarani
, Chiung Yao Huang
, Tsong Long Hwang
, Chang Feng Dai
, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

11 Scopus citations

Abstract

Two new tocopherol-derived metabolites, hirsutocospiro A (1) and hirsutocoquinone A (2), were isolated from the soft coral Cladiella hirsuta. The structures of 1 and 2 were determined by extensive spectroscopic analysis. The in vitro anti-inflammatory activity of compounds 1 and 2 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. Compound 1 was shown to exhibit significant anti-inflammatory activity.

Original language	English
Pages (from-to)	92-95
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2014.11.002
State	Published - 01 01 2015

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© 2014 Elsevier Ltd. All rights reserved.

Keywords

Anti-inflammatory activity
Cladiella hirsute
Hirsutaquinone

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10.1016/j.bmcl.2014.11.002

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abstract = "Two new tocopherol-derived metabolites, hirsutocospiro A (1) and hirsutocoquinone A (2), were isolated from the soft coral Cladiella hirsuta. The structures of 1 and 2 were determined by extensive spectroscopic analysis. The in vitro anti-inflammatory activity of compounds 1 and 2 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. Compound 1 was shown to exhibit significant anti-inflammatory activity.",

keywords = "Anti-inflammatory activity, Cladiella hirsute, Hirsutaquinone",

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doi = "10.1016/j.bmcl.2014.11.002",

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AU - Chen, Bo Wei

AU - Uvarani, Chokkalingam

AU - Huang, Chiung Yao

AU - Hwang, Tsong Long

AU - Dai, Chang Feng

AU - Sheu, Jyh Horng

PY - 2015/1/1

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AB - Two new tocopherol-derived metabolites, hirsutocospiro A (1) and hirsutocoquinone A (2), were isolated from the soft coral Cladiella hirsuta. The structures of 1 and 2 were determined by extensive spectroscopic analysis. The in vitro anti-inflammatory activity of compounds 1 and 2 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. Compound 1 was shown to exhibit significant anti-inflammatory activity.

KW - Anti-inflammatory activity

KW - Cladiella hirsute

KW - Hirsutaquinone

UR - https://www.scopus.com/pages/publications/84913528969

U2 - 10.1016/j.bmcl.2014.11.002

DO - 10.1016/j.bmcl.2014.11.002

M3 - 文章

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AN - SCOPUS:84913528969

SN - 0960-894X

VL - 25

SP - 92

EP - 95

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

New anti-inflammatory tocopherol-derived metabolites from the Taiwanese soft coral Cladiella hirsuta

Abstract

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Keywords

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