New bioactive Δ11(17)-furanoeunicellins from an octocoral Cladiella sp.

Ying Fa Chen, Wu Fu Chen, Zhi Hong Wen, Tsong Long Hwang, Zhi Jun Zhang, Ping Jyun Sung*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

9 Scopus citations

Abstract

A new eunicellin diterpenoid, cladieunicellin U (1), along with a new natural eunicellin, cladieunicellin V (2), and two known analogues, sclerophytins A (3) and B (4), were obtained from an octocoral identified as Cladiella sp. The structures, including the absolute configurations, of eunicellins 1–4 were elucidated by using spectroscopic methods and compared with the spectroscopic and physical data reported in the literature. Eunicellins 1, 3 and 4 decreased the release of elastase, while eunicellins 2 and 4 showed inhibitory effects in terms of the generation of superoxide anions by human neutrophils. Eunicellins 1 and 4 were found to show moderate cytotoxicity toward the leukemia K562 cells (IC50 = 12.8, 11.4 μg/mL, respectively) and 2 exhibited moderate cytotoxicity toward the leukemia MOLT-4 cells (IC50 = 18.8 μg/mL).

Original languageEnglish
Pages (from-to)31-35
Number of pages5
JournalPhytochemistry Letters
Volume33
DOIs
StatePublished - 10 2019

Bibliographical note

Publisher Copyright:
© 2019 Phytochemical Society of Europe

Keywords

  • Cladiella
  • Cladieunicellin
  • Cytotoxicity
  • Elastase
  • Sclerophytin
  • Superoxide anion

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