New bioactive steroids from the soft coral Klyxum flaccidum

Chia Ruei Tsai; Chiung Yao Huang; Bo Wei Chen; Yi Ying Tsai; Shou Ping Shih; Tsong Long Hwang; Chang Feng Dai; Sheng Yang Wang; Jyh Horng Sheu

doi:10.1039/c4ra13977a

New bioactive steroids from the soft coral Klyxum flaccidum

Chia Ruei Tsai, Chiung Yao Huang, Bo Wei Chen, Yi Ying Tsai, Shou Ping Shih, Tsong Long Hwang, Chang Feng Dai, Sheng Yang Wang, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

30 Scopus citations

Abstract

Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.

Original language	English
Pages (from-to)	12546-12554
Number of pages	9
Journal	RSC Advances
Volume	5
Issue number	17
DOIs	https://doi.org/10.1039/c4ra13977a
State	Published - 2015

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© The Royal Society of Chemistry 2015.

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title = "New bioactive steroids from the soft coral Klyxum flaccidum",

abstract = "Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.",

author = "Tsai, {Chia Ruei} and Huang, {Chiung Yao} and Chen, {Bo Wei} and Tsai, {Yi Ying} and Shih, {Shou Ping} and Hwang, {Tsong Long} and Dai, {Chang Feng} and Wang, {Sheng Yang} and Sheu, {Jyh Horng}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

doi = "10.1039/c4ra13977a",

language = "英语",

volume = "5",

pages = "12546--12554",

journal = "RSC Advances",

issn = "2046-2069",

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T1 - New bioactive steroids from the soft coral Klyxum flaccidum

AU - Tsai, Chia Ruei

AU - Huang, Chiung Yao

AU - Chen, Bo Wei

AU - Tsai, Yi Ying

AU - Shih, Shou Ping

AU - Hwang, Tsong Long

AU - Dai, Chang Feng

AU - Wang, Sheng Yang

AU - Sheu, Jyh Horng

PY - 2015

Y1 - 2015

N2 - Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.

AB - Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.

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U2 - 10.1039/c4ra13977a

DO - 10.1039/c4ra13977a

M3 - 文章

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SN - 2046-2069

VL - 5

SP - 12546

EP - 12554

JO - RSC Advances

JF - RSC Advances

IS - 17

ER -

New bioactive steroids from the soft coral Klyxum flaccidum

Abstract

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