New bioactive steroids from the soft coral Klyxum flaccidum

Chia Ruei Tsai; Chiung Yao Huang; Bo Wei Chen; Yi Ying Tsai; Shou Ping Shih; Tsong Long Hwang; Chang Feng Dai; Sheng Yang Wang; Jyh Horng Sheu

doi:10.1039/c4ra13977a

New bioactive steroids from the soft coral Klyxum flaccidum

Chia Ruei Tsai
, Chiung Yao Huang
, Bo Wei Chen
, Yi Ying Tsai
, Shou Ping Shih
, Tsong Long Hwang
, Chang Feng Dai
, Sheng Yang Wang
, Jyh Horng Sheu^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

34 Scopus citations

Abstract

Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.

Original language	English
Pages (from-to)	12546-12554
Number of pages	9
Journal	RSC Advances
Volume	5
Issue number	17
DOIs	https://doi.org/10.1039/c4ra13977a
State	Published - 2015

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© The Royal Society of Chemistry 2015.

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10.1039/c4ra13977a

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@article{06e686a43e2e43019fa6607b935f5e0a,

title = "New bioactive steroids from the soft coral Klyxum flaccidum",

abstract = "Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.",

author = "Tsai, \{Chia Ruei\} and Huang, \{Chiung Yao\} and Chen, \{Bo Wei\} and Tsai, \{Yi Ying\} and Shih, \{Shou Ping\} and Hwang, \{Tsong Long\} and Dai, \{Chang Feng\} and Wang, \{Sheng Yang\} and Sheu, \{Jyh Horng\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

doi = "10.1039/c4ra13977a",

language = "英语",

volume = "5",

pages = "12546--12554",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "17",

}

TY - JOUR

T1 - New bioactive steroids from the soft coral Klyxum flaccidum

AU - Tsai, Chia Ruei

AU - Huang, Chiung Yao

AU - Chen, Bo Wei

AU - Tsai, Yi Ying

AU - Shih, Shou Ping

AU - Hwang, Tsong Long

AU - Dai, Chang Feng

AU - Wang, Sheng Yang

AU - Sheu, Jyh Horng

PY - 2015

Y1 - 2015

N2 - Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.

AB - Six new steroids, klyflaccisteroids A-E (1-5) and a new 9,11-secogorgosteroid klyflaccisteroid F (6), along with two known steroids 9,11-secosteroid 3β,11-dihydroxy-9,11-secogorgost-5-en-9-one (7) and gorgost-5-ene-3β,9α,11α-triol (8), and a known eunicellin-based diterpenoid cladiellisin (9), were discovered from the soft coral K. flaccidum. Compound 6 is the first 9,11-secogorgosteroid 11-carboxylic acid isolated from natural sources. Cytotoxicity of these compounds and anti-inflammatory activities of 1-4 and 6-9 were also evaluated. Some compounds were shown to exhibit attractive bioactivities.

UR - https://www.scopus.com/pages/publications/84961298529

U2 - 10.1039/c4ra13977a

DO - 10.1039/c4ra13977a

M3 - 文章

AN - SCOPUS:84961298529

SN - 2046-2069

VL - 5

SP - 12546

EP - 12554

JO - RSC Advances

JF - RSC Advances

IS - 17

ER -

New bioactive steroids from the soft coral Klyxum flaccidum

Abstract

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