New briarane diterpenoids from Taiwanese soft coral: Briareum violacea

Chia Ching Liaw; Yuan Bin Cheng; Yun Sheng Lin; Yao Haur Kuo; Tsong Long Hwang; Ya Ching Shen

doi:10.3390/md12084677

New briarane diterpenoids from Taiwanese soft coral: Briareum violacea

Chia Ching Liaw, Yuan Bin Cheng, Yun Sheng Lin, Yao Haur Kuo, Tsong Long Hwang, Ya Ching Shen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

Ten new briarane diterpenoids, briaviolides A-J (1-10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (¹H- and ¹³C-NMR, ¹H-¹H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/Cytochalasin B (fMLP/CB).

Original language	English
Pages (from-to)	4677-4692
Number of pages	16
Journal	Marine Drugs
Volume	12
Issue number	8
DOIs	https://doi.org/10.3390/md12084677
State	Published - 01 08 2014

Bibliographical note

Publisher Copyright:
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

Keywords

Anti-inflammatory activities
Briarane diterpenoids
Briareum violacea
Briaviolides

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10.3390/md12084677

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@article{875244c63be24994a3576a658c274b75,

title = "New briarane diterpenoids from Taiwanese soft coral: Briareum violacea",

abstract = "Ten new briarane diterpenoids, briaviolides A-J (1-10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (1H- and 13C-NMR, 1H-1H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/Cytochalasin B (fMLP/CB).",

keywords = "Anti-inflammatory activities, Briarane diterpenoids, Briareum violacea, Briaviolides",

author = "Liaw, {Chia Ching} and Cheng, {Yuan Bin} and Lin, {Yun Sheng} and Kuo, {Yao Haur} and Hwang, {Tsong Long} and Shen, {Ya Ching}",

note = "Publisher Copyright: {\textcopyright} 2014 by the authors; licensee MDPI, Basel, Switzerland.",

year = "2014",

month = aug,

day = "1",

doi = "10.3390/md12084677",

language = "英语",

volume = "12",

pages = "4677--4692",

journal = "Marine Drugs",

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TY - JOUR

T1 - New briarane diterpenoids from Taiwanese soft coral

T2 - Briareum violacea

AU - Liaw, Chia Ching

AU - Cheng, Yuan Bin

AU - Lin, Yun Sheng

AU - Kuo, Yao Haur

AU - Hwang, Tsong Long

AU - Shen, Ya Ching

PY - 2014/8/1

Y1 - 2014/8/1

N2 - Ten new briarane diterpenoids, briaviolides A-J (1-10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (1H- and 13C-NMR, 1H-1H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/Cytochalasin B (fMLP/CB).

AB - Ten new briarane diterpenoids, briaviolides A-J (1-10), together with six known briaranes, solenolides A and D, excavatolide A, briaexcavatolide I, 4β-acetoxy-9-deacetystylatulide lactone and 9-deacetylstylatulide lactone, were isolated from the Taiwanese soft coral, Briareum violacea. Their structures were determined on the basis of spectroscopic data (1H- and 13C-NMR, 1H-1H COSY, HSQC, HMBC and NOESY), HR-MS and chemical methods. The absolute configuration of briaviolide A (1) was determined by X-ray crystallographic analysis. Compounds 5, 9 and derivative 11 showed moderate inhibitory activities on superoxide-anion generation and elastase release by human neutrophils in response to N-formyl-methionyl-leucyl-phenylalanine/Cytochalasin B (fMLP/CB).

KW - Anti-inflammatory activities

KW - Briarane diterpenoids

KW - Briareum violacea

KW - Briaviolides

UR - http://www.scopus.com/inward/record.url?scp=84908065180&partnerID=8YFLogxK

U2 - 10.3390/md12084677

DO - 10.3390/md12084677

M3 - 文章

C2 - 25153765

AN - SCOPUS:84908065180

SN - 1660-3397

VL - 12

SP - 4677

EP - 4692

JO - Marine Drugs

JF - Marine Drugs

IS - 8

ER -

New briarane diterpenoids from Taiwanese soft coral: Briareum violacea

Abstract

Bibliographical note

Keywords

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