New briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae)

Ping Jyun Sung; Mei Ru Lin; Yin Di Su; Michael Y. Chiang; Wan Ping Hu; Jui Hsin Su; Mo Chih Cheng; Tsong Long Hwang; Jyh Horng Sheu

doi:10.1016/j.tet.2008.01.023

New briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae)

Ping Jyun Sung^*, Mei Ru Lin, Yin Di Su, Michael Y. Chiang, Wan Ping Hu, Jui Hsin Su, Mo Chih Cheng, Tsong Long Hwang, Jyh Horng Sheu

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

49 Scopus citations

Abstract

Six 12-hydroxybriaranes, including four new diterpenoids, briaexcavatins I-L (1-4), and two known metabolites, excavatolides C (5) and E (6), have been isolated from the cultured scleraxonia Briareum excavatum. In addition, the gorgonian coral Junceella fragilis yielded a new chlorinated briarane, fragilide C (10). The structures of above compounds were determined by spectroscopic methods and the structures of 5 and 6 were further confirmed by X-ray data analysis for the first time. The absolute configuration of 6 was elucidated by chemical conversion. Some of these briaranes have displayed inhibitory effects on superoxide anion generation by human neutrophils.

Original language	English
Pages (from-to)	2596-2604
Number of pages	9
Journal	Tetrahedron
Volume	64
Issue number	11
DOIs	https://doi.org/10.1016/j.tet.2008.01.023
State	Published - 10 03 2008

Keywords

Briaexcavatin
Briarane
Briareum excavatum
Fragilide
Junceella fragilis
Superoxide anion

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10.1016/j.tet.2008.01.023

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@article{83544ba24edf4a9b86b93b4f172e53f8,

title = "New briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae)",

abstract = "Six 12-hydroxybriaranes, including four new diterpenoids, briaexcavatins I-L (1-4), and two known metabolites, excavatolides C (5) and E (6), have been isolated from the cultured scleraxonia Briareum excavatum. In addition, the gorgonian coral Junceella fragilis yielded a new chlorinated briarane, fragilide C (10). The structures of above compounds were determined by spectroscopic methods and the structures of 5 and 6 were further confirmed by X-ray data analysis for the first time. The absolute configuration of 6 was elucidated by chemical conversion. Some of these briaranes have displayed inhibitory effects on superoxide anion generation by human neutrophils.",

keywords = "Briaexcavatin, Briarane, Briareum excavatum, Fragilide, Junceella fragilis, Superoxide anion",

author = "Sung, {Ping Jyun} and Lin, {Mei Ru} and Su, {Yin Di} and Chiang, {Michael Y.} and Hu, {Wan Ping} and Su, {Jui Hsin} and Cheng, {Mo Chih} and Hwang, {Tsong Long} and Sheu, {Jyh Horng}",

year = "2008",

month = mar,

day = "10",

doi = "10.1016/j.tet.2008.01.023",

language = "英语",

volume = "64",

pages = "2596--2604",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

number = "11",

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TY - JOUR

T1 - New briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae)

AU - Sung, Ping Jyun

AU - Lin, Mei Ru

AU - Su, Yin Di

AU - Chiang, Michael Y.

AU - Hu, Wan Ping

AU - Su, Jui Hsin

AU - Cheng, Mo Chih

AU - Hwang, Tsong Long

AU - Sheu, Jyh Horng

PY - 2008/3/10

Y1 - 2008/3/10

N2 - Six 12-hydroxybriaranes, including four new diterpenoids, briaexcavatins I-L (1-4), and two known metabolites, excavatolides C (5) and E (6), have been isolated from the cultured scleraxonia Briareum excavatum. In addition, the gorgonian coral Junceella fragilis yielded a new chlorinated briarane, fragilide C (10). The structures of above compounds were determined by spectroscopic methods and the structures of 5 and 6 were further confirmed by X-ray data analysis for the first time. The absolute configuration of 6 was elucidated by chemical conversion. Some of these briaranes have displayed inhibitory effects on superoxide anion generation by human neutrophils.

AB - Six 12-hydroxybriaranes, including four new diterpenoids, briaexcavatins I-L (1-4), and two known metabolites, excavatolides C (5) and E (6), have been isolated from the cultured scleraxonia Briareum excavatum. In addition, the gorgonian coral Junceella fragilis yielded a new chlorinated briarane, fragilide C (10). The structures of above compounds were determined by spectroscopic methods and the structures of 5 and 6 were further confirmed by X-ray data analysis for the first time. The absolute configuration of 6 was elucidated by chemical conversion. Some of these briaranes have displayed inhibitory effects on superoxide anion generation by human neutrophils.

KW - Briaexcavatin

KW - Briarane

KW - Briareum excavatum

KW - Fragilide

KW - Junceella fragilis

KW - Superoxide anion

UR - http://www.scopus.com/inward/record.url?scp=38949099695&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2008.01.023

DO - 10.1016/j.tet.2008.01.023

M3 - 文章

AN - SCOPUS:38949099695

SN - 0040-4020

VL - 64

SP - 2596

EP - 2604

JO - Tetrahedron

JF - Tetrahedron

IS - 11

ER -

New briaranes from the octocorals Briareum excavatum (Briareidae) and Junceella fragilis (Ellisellidae)

Abstract

Keywords

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