TY - JOUR
T1 - New coumarin derivatives and other constituents from the stem bark of zanthoxylum avicennae
T2 - Effects on neutrophil pro-inflammatory responses
AU - Chen, Jih Jung
AU - Yang, Chieh Kai
AU - Kuo, Yueh Hsiung
AU - Hwang, Tsong Long
AU - Kuo, Wen Lung
AU - Lim, Yun Ping
AU - Sung, Ping Jyun
AU - Chang, Tsung Hsien
AU - Cheng, Ming Jen
N1 - Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2015/4/29
Y1 - 2015/4/29
N2 - Three new coumarin derivatives, 8-formylalloxanthoxyletin (1), avicennone (2), and (Z)-avicennone (3), have been isolated from the stem bark of Zanthoxylum avicennae (Z. avicennae), together with 15 known compounds (4–18). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4, 9, 12, and 15 exhibited inhibition (half maximal inhibitory concentration (IC50) values ≤7.65 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-Lleucyl- L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, 2, 4, 8 and 9 inhibited fMLP/CB-induced elastase release with IC50 values ≤8.17 μg/mL. This investigation reveals bioactive isolates (especially 1, 2, 4, 8, 9, 12 and 15) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
AB - Three new coumarin derivatives, 8-formylalloxanthoxyletin (1), avicennone (2), and (Z)-avicennone (3), have been isolated from the stem bark of Zanthoxylum avicennae (Z. avicennae), together with 15 known compounds (4–18). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4, 9, 12, and 15 exhibited inhibition (half maximal inhibitory concentration (IC50) values ≤7.65 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-Lleucyl- L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 1, 2, 4, 8 and 9 inhibited fMLP/CB-induced elastase release with IC50 values ≤8.17 μg/mL. This investigation reveals bioactive isolates (especially 1, 2, 4, 8, 9, 12 and 15) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
KW - Anti-inflammatory activity
KW - Coumarin
KW - Rutaceae
KW - Structure elucidation
KW - Zanthoxylum avicennae
UR - https://www.scopus.com/pages/publications/84929379614
U2 - 10.3390/ijms16059719
DO - 10.3390/ijms16059719
M3 - 文章
C2 - 25938967
AN - SCOPUS:84929379614
SN - 1661-6596
VL - 16
SP - 9719
EP - 9731
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 5
ER -