TY - JOUR
T1 - New flavones, a 2-(2-phenylethyl)-4H-chromen-4-one derivative, and anti-inflammatory constituents from the stem barks of Aquilaria sinensis
AU - Wang, Sin Ling
AU - Hwang, Tsong Long
AU - Chung, Mei Ing
AU - Sung, Ping Jyun
AU - Shu, Chih Wen
AU - Cheng, Ming Jen
AU - Chen, Jih Jung
N1 - Publisher Copyright:
© 2015 by The Authors.
PY - 2015/11/24
Y1 - 2015/11/24
N2 - In the current study, two new flavones, 4′-O-geranyltricin (1) and 3′-O-geranylpolloin (2), and a new 2-(2-phenylethyl)-4H-chromen-4-one derivative, 7-hydroxyl-6-methoxy-2-(2-phenylethyl)chromone (3), have been isolated from the stem barks of A. sinensis, together with 21 known compounds 4-24. The structures of new compounds 1-3 were determined through spectroscopic and MS analyses. Compounds 2, 3, 5, 6, and 8-10 exhibited inhibition (IC50 ≤ 12.51 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3, 6, 8, 10, and 19 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 15.25 μM. This investigation reveals bioactive isolates (especially 2, 3, 5, 6, 8, 9, 10, and 19) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
AB - In the current study, two new flavones, 4′-O-geranyltricin (1) and 3′-O-geranylpolloin (2), and a new 2-(2-phenylethyl)-4H-chromen-4-one derivative, 7-hydroxyl-6-methoxy-2-(2-phenylethyl)chromone (3), have been isolated from the stem barks of A. sinensis, together with 21 known compounds 4-24. The structures of new compounds 1-3 were determined through spectroscopic and MS analyses. Compounds 2, 3, 5, 6, and 8-10 exhibited inhibition (IC50 ≤ 12.51 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3, 6, 8, 10, and 19 inhibited fMLP/CB-induced elastase release with IC50 values ≤ 15.25 μM. This investigation reveals bioactive isolates (especially 2, 3, 5, 6, 8, 9, 10, and 19) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
KW - 2-(2-phenylethyl)-4H-chromen-4-one
KW - Anti-inflammatory activity
KW - Aquilaria sinensis
KW - Flavone
KW - Structure elucidation
KW - Thymelaeaceae
UR - https://www.scopus.com/pages/publications/84949985065
U2 - 10.3390/molecules201119736
DO - 10.3390/molecules201119736
M3 - 文章
C2 - 26610457
AN - SCOPUS:84949985065
SN - 1420-3049
VL - 20
SP - 20912
EP - 20925
JO - Molecules
JF - Molecules
IS - 11
ER -