TY - JOUR
T1 - New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium
AU - Chen, Jih Jung
AU - Ting, Chia Wei
AU - Wu, Yi Chin
AU - Hwang, Tsong Long
AU - Cheng, Ming Jen
AU - Sung, Ping Jyun
AU - Wang, Tai Chi
AU - Chen, Jinn Fen
PY - 2013
Y1 - 2013
N2 - Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.
AB - Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.
UR - https://www.scopus.com/pages/publications/84901645086
U2 - 10.3390/ijms140713063
DO - 10.3390/ijms140713063
M3 - 文章
C2 - 23799360
AN - SCOPUS:84901645086
SN - 1661-6596
VL - 14
SP - 13063
EP - 13077
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 7
ER -