New molecular insights into cellular survival and stress responses: Neuroprotective role of cellular prion protein (PrPC)

Raymond Yen Yu Lo; Woei Cherng Shyu; Shinn Zong Lin; Hsiao Jung Wang; Shun Sheng Chen; Hung Li

doi:10.1007/s12035-007-8003-y

New molecular insights into cellular survival and stress responses: Neuroprotective role of cellular prion protein (PrP^C)

Raymond Yen Yu Lo, Woei Cherng Shyu^*, Shinn Zong Lin, Hsiao Jung Wang, Shun Sheng Chen, Hung Li

^*Corresponding author for this work

School of Medicine

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt-Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.

Original language	English
Pages (from-to)	236-244
Number of pages	9
Journal	Molecular Neurobiology
Volume	35
Issue number	3
DOIs	https://doi.org/10.1007/s12035-007-8003-y
State	Published - 06 2007

Keywords

Cell survival
Neuroprotection
Oxidative stress
PrPc
Prion
TSE

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10.1007/s12035-007-8003-y

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abstract = "Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt-Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.",

keywords = "Cell survival, Neuroprotection, Oxidative stress, PrPc, Prion, TSE",

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AU - Shyu, Woei Cherng

AU - Lin, Shinn Zong

AU - Wang, Hsiao Jung

AU - Chen, Shun Sheng

AU - Li, Hung

PY - 2007/6

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AB - Knowledge of the physiological function of cellular prion protein has been acquired from prion diseases such as Creutzfeldt-Jakob disease, as well as PRNP knock out and transgenic mice. Recent progress in neurobiology has further delineated the neuroprotective role played by cellular prion protein. In this paper, we review the role of cellular prion protein in cell survival including its antiapoptotic effect on Bax-mediated cell death and its responses to various environmental stresses including oxidative stress, and ischemia. Finally, we discuss the significance of cellular prion protein in different neurodegenerative diseases and the possible development of future therapies.

KW - Cell survival

KW - Neuroprotection

KW - Oxidative stress

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KW - TSE

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M3 - 文献综述

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JO - Molecular Neurobiology

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New molecular insights into cellular survival and stress responses: Neuroprotective role of cellular prion protein (PrP^C)

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Keywords

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