New verticillane diterpenoids from cespitularia taeniata

Jiun Yang Chang; Ahmed Eid Fazary; Yu Chi Lin; Tsong Long Hwang; Ya Ching Shen

doi:10.1002/cbdv.201100122

New verticillane diterpenoids from cespitularia taeniata

Jiun Yang Chang, Ahmed Eid Fazary, Yu Chi Lin, Tsong Long Hwang, Ya Ching Shen^*

^*Corresponding author for this work

School of Traditional Chinese Medicine

Research output: Contribution to journal › Journal Article › peer-review

17 Scopus citations

Abstract

Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins E-G (1-3, resp.). The structures of these compounds were elucidated by spectroscopic analysis, especially HR-MS and 2D-NMR techniques. Compound 1 possesses a rare norverticillane skeleton with two adjacent OH groups at C(5) and C(6), while the seco-compound 2 with an aldehyde group at C(9) results from an unusual bond cleavage between C(9) and C(10). Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide-anion generation and elastase release by human neutrophils in response to FMLP/CB. A plausible biogenetic pathway for compound 2 is also discussed.

Original language	English
Pages (from-to)	654-661
Number of pages	8
Journal	Chemistry and Biodiversity
Volume	9
Issue number	3
DOIs	https://doi.org/10.1002/cbdv.201100122
State	Published - 03 2012

Keywords

Anti-inflammatory activity
Cespitularia taeniata
Cespitulins E - G
Diterpenoids
Soft corals
Verticillane diterpenoids

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10.1002/cbdv.201100122

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title = "New verticillane diterpenoids from cespitularia taeniata",

abstract = "Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins E-G (1-3, resp.). The structures of these compounds were elucidated by spectroscopic analysis, especially HR-MS and 2D-NMR techniques. Compound 1 possesses a rare norverticillane skeleton with two adjacent OH groups at C(5) and C(6), while the seco-compound 2 with an aldehyde group at C(9) results from an unusual bond cleavage between C(9) and C(10). Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide-anion generation and elastase release by human neutrophils in response to FMLP/CB. A plausible biogenetic pathway for compound 2 is also discussed.",

keywords = "Anti-inflammatory activity, Cespitularia taeniata, Cespitulins E - G, Diterpenoids, Soft corals, Verticillane diterpenoids",

author = "Chang, \{Jiun Yang\} and Fazary, \{Ahmed Eid\} and Lin, \{Yu Chi\} and Hwang, \{Tsong Long\} and Shen, \{Ya Ching\}",

year = "2012",

month = mar,

doi = "10.1002/cbdv.201100122",

language = "英语",

volume = "9",

pages = "654--661",

journal = "Chemistry and Biodiversity",

issn = "1612-1872",

publisher = "Wiley-Blackwell",

number = "3",

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TY - JOUR

T1 - New verticillane diterpenoids from cespitularia taeniata

AU - Chang, Jiun Yang

AU - Fazary, Ahmed Eid

AU - Lin, Yu Chi

AU - Hwang, Tsong Long

AU - Shen, Ya Ching

PY - 2012/3

Y1 - 2012/3

N2 - Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins E-G (1-3, resp.). The structures of these compounds were elucidated by spectroscopic analysis, especially HR-MS and 2D-NMR techniques. Compound 1 possesses a rare norverticillane skeleton with two adjacent OH groups at C(5) and C(6), while the seco-compound 2 with an aldehyde group at C(9) results from an unusual bond cleavage between C(9) and C(10). Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide-anion generation and elastase release by human neutrophils in response to FMLP/CB. A plausible biogenetic pathway for compound 2 is also discussed.

AB - Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins E-G (1-3, resp.). The structures of these compounds were elucidated by spectroscopic analysis, especially HR-MS and 2D-NMR techniques. Compound 1 possesses a rare norverticillane skeleton with two adjacent OH groups at C(5) and C(6), while the seco-compound 2 with an aldehyde group at C(9) results from an unusual bond cleavage between C(9) and C(10). Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide-anion generation and elastase release by human neutrophils in response to FMLP/CB. A plausible biogenetic pathway for compound 2 is also discussed.

KW - Anti-inflammatory activity

KW - Cespitularia taeniata

KW - Cespitulins E - G

KW - Diterpenoids

KW - Soft corals

KW - Verticillane diterpenoids

UR - https://www.scopus.com/pages/publications/84859018723

U2 - 10.1002/cbdv.201100122

DO - 10.1002/cbdv.201100122

M3 - 文章

C2 - 22422532

AN - SCOPUS:84859018723

SN - 1612-1872

VL - 9

SP - 654

EP - 661

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 3

ER -

New verticillane diterpenoids from cespitularia taeniata

Abstract

Keywords

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