Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers

Yu Chung Tsao, Po Wen Gu, Su Hsun Liu, I. Shiang Tzeng, Jau Yuan Chen, Jiin Chyuan John Luo*

*Corresponding author for this work

Research output: Contribution to journalJournal Article peer-review

20 Scopus citations

Abstract

Context: The mechanism of nickel-induced pathogenesis remains elusive. Objective: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers. Materials and methods: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models. Results: Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment. Discussion and conclusion: Exposure to high levels of nickel may reduce serum anti-oxidative capacity.

Original languageEnglish
Pages (from-to)455-460
Number of pages6
JournalBiomarkers
Volume22
Issue number5
DOIs
StatePublished - 04 07 2017

Bibliographical note

Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

  • Nickel
  • biomarkers
  • oxidative stress

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